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AKAP8 encodes a member of the A-kinase anchor protein family. De plus, nous expédions AKAP8 Protéines (4) et AKAP8 Kits (1) et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Polyclonal AKAP8 Primary Antibody pour ELISA, WB - ABIN250209
Eide, Coghlan, Orstavik, Holsve, Solberg, Skâlhegg, Lamb, Langeberg, Fernandez, Scott, Jahnsen, Taskén: Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. dans Experimental cell research 1998
Human Polyclonal AKAP8 Primary Antibody pour FACS, ICC - ABIN4278933
Li, Kao, Garcia, Shabanowitz, Hunt, Qin, Phelan, Lazar: A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. dans Genes & development 2006
These results establish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation.
Results suggest that ALK generated by alternative transcription Initiation induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus.
Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area.
Report expression of connexin 43 (Montrer GJA1 Anticorps) in ovarian cancer cells in G1/S phase.
The data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production.
Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L (Montrer AKAP8L Anticorps) in particular, play an important role in modulation of head size and may contribute to autism risk.
These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation.
Ectopic AKAP95 stimulates expression of a chromosomal reporter gene in synergy with MLL1 or MLL2 (Montrer MLL2 Anticorps), whereas AKAP95 depletion impairs retinoic acid-mediated gene induction in embryonic stem cells
AMY-1 (Montrer AMY1A Anticorps) interacts with S-AKAP84 (Montrer AKAP1 Anticorps) and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase (Montrer CDK7 Anticorps) activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (Montrer AKAP13 Anticorps) (AKAP (Montrer AKAP1 Anticorps)) complex.
role of AKAP95 in DNA replication by providing a scaffold for MCM2 (Montrer MCM2 Anticorps)
This study showed an increase in the level of global DNA methylation (Montrer HELLS Anticorps) starting in oocytes with diameters around 60 microm, increases in histone h4 (Montrer HIST1H4H Anticorps), and decreases in AKAP95.
a specific role for A kinase-anchoring protein (Montrer MYRIP Anticorps) 95 in suppressing the expression of the gene encoding tumor necrosis factor-alpha (Montrer TNF Anticorps), which involved phosphorylation of p105 (Montrer NEDD9 Anticorps) (also known as Nfkb1 (Montrer NFKB1 Anticorps)) by PKA
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9.
A kinase (PRKA) anchor protein 8
, A-kinase anchor protein 8
, A-kinase anchor protein 8-like
, a-kinase anchor protein 8-like
, A-kinase anchor protein, 95kDa
, A kinase anchor protein 8
, A kinase anchor protein 95
, A-kinase anchor protein 95 kDa
, AKAP 95
, protein kinase A-anchoring protein 95