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ADAM2 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.
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Human Polyclonal ADAM2 Primary Antibody pour IHC, IHC (p) - ABIN4278223
Maheswaran, Pedersen, Ditzel, Gjerstorff: Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer. dans PLoS ONE 2015
Characterization of promoter and repressor regions that regulate the transcription of the mouse Adam2 gene.
data indicate that ITGA9-ITGB7 (Montrer ITGB7 Anticorps) functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function
we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation.
role of CD9 (Montrer CD9 Anticorps) in the strengthening of fertilin beta-mediated cell adhesion
Because fertilin beta is absent from calmegin (Montrer CLGN Anticorps)-deficient mice, the role of fertilin beta in sperm-EPM (Montrer STX2 Anticorps) interaction needs to be reevaluated.
ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm
ADAM2 is involved in protein trafficking during sperm development
These results suggest that mouse ADAM1b/ADAM2 fertilin may play a crucial role not in the sperm/egg fusion but in the appearance of these two ADAMs on the sperm surface.
Results suggest that association with ADAM2 is a key element for stability of ADAM3 in epididymal sperm, and the presence of the ADAM2-ADAM3 complex in sperm also suggests a potential role of ADAM2 with ADAM3 in sperm binding to the egg zona pellucida.
ADAM2 contributes to migration from the subventricular zone along the rostral migratory stream, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint.
ADAM2, CALR3 and SAGE1 cancer/testis antigens are not promising targets for immunotherapy of breast and lung cancer.
The fertilin beta contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
, a disintegrin and metalloprotease domain 2 (fertilin beta)
, disintegrin and metalloproteinase domain-containing protein 2
, fertilin beta
, fertilin subunit beta
, cancer/testis antigen 15
, A disintegrin and metalloprotease domain 2 (Fertilin beta)
, a disintegrin and metallopeptidase domain 2
, a disintegrin and metalloprotease domain 2
, a disintegrin and metalloprotease domain (ADAM) 2
, ADAM metallopeptidase domain 2 (fertilin beta)
, a disintegrin and metalloproteinase domain 2 (fertilin beta)
, fertilin beta subunit