ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 Protéines (Adamts2)

Adamts2 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. De plus, nous expédions Adamts2 Anticorps (42) et Adamts2 Kits (19) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Adamts2 216725 Q8C9W3
Adamts2 9509 O95450
Rat Adamts2 Adamts2 287899  
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Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Escherichia coli (E. coli) Souris His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$608.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Boeuf (Vache) His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$640.00
Détails

Adamts2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Human ,
,

Plus protéines pour ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) partenaires d'interaction

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. ADAMTS2 plays a critical role in cardiac hypertrophy induced by pressure overload in mouse model.

  2. Data show that the high titer and specific rabbit anti-ADAMTS2 antibody has been prepared successfully.

  3. There is no significant genotype effect of ADAMTS2 on age, height, weight, BMI or sex on risk of Achilles tendon pathology.

  4. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.

  5. The extent of liver fibrosis is reduced in ADAMTS2-deficient mice in comparison with their wild type littermates.

  6. Data show thatincreased mRNA of Lamb3 (Montrer LAMB3 Protéines) and Adamts2 and enhanced activities of metalloproteinases MMP1 (Montrer MMP1 Protéines), 2 and 7 in transgenic mice expressing the HLA-DQ8.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families

  2. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review]

  3. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression.

  4. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD

  5. Pathway inhibition studies revealed that ADAMTS-2 (Montrer ADAMTS4 Protéines) upregulation by IL-6 (Montrer IL6 Protéines) was mediated by JNK (Montrer MAPK8 Protéines) pathway.

  6. ADAMTS-2 (Montrer ADAMTS4 Protéines), -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI (Montrer CFD Protéines) compared those associated with stable angina.

  7. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.

  8. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein.

  9. when conditioned media of TSP2 (Montrer THBS2 Protéines)-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 (Montrer THBS2 Protéines) is a potential inhibitor of angiogenesis

  10. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V

Profil protéine Adamts2

Profil protéine

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Adamts2

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 (Adamts2)
  • ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 2 (Adamts2)
  • ADAM-TS2 Protéine
  • ADAMTS-2 Protéine
  • ADAMTS-3 Protéine
  • hPCPNI Protéine
  • mKIAA4060 Protéine
  • NPI Protéine
  • PC I-NP Protéine
  • PCI-NP Protéine
  • PCINP Protéine
  • PCPNI Protéine
  • PNPI Protéine
  • RGD1565950 Protéine

Protein level used designations for Adamts2

A disintegrin and metalloproteinase with thrombospondin motifs 2 , ADAM-TS 2 , PC I-NP , a disintegrin and metalloproteinase with thrombospondin repeats , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 , procollagen I/II amino propeptide-processing enzyme , procollagen N-endopeptidase , procollagen N-proteinase , procollagen I N-proteinase , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 , ADAM-TS2 , ADAMTS-2 , pNPI

GENE ID SPECIES
216725 Mus musculus
9509 Homo sapiens
287899 Rattus norvegicus
416291 Gallus gallus
481453 Canis lupus familiaris
282401 Bos taurus
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