ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Protéines (ADAMTS18)

ADAMTS18 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. De plus, nous expédions ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Anticorps (44) et ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Kits (22) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ADAMTS18 208936 Q4VC17
ADAMTS18 170692 Q8TE60
Rat ADAMTS18 ADAMTS18 361412  
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Top ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Protéines sur anticorps-enligne.fr

Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

ADAMTS18 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) partenaires d'interaction

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) interaction partners

  1. The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation.

  2. Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model.

  3. these data demonstrate a thrombin (Montrer F2 Protéines) cleavage site and confirm a short form of ADAMTS-18 presents in vivo.

  4. Adamts18 is expressed in the lens and retina in the developing murine eye.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18) interaction partners

  1. In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT (Montrer AKT1 Protéines) and NF-kappaB (Montrer NFKB1 Protéines) signaling, further suppressing EMT (Montrer ITK Protéines) and metastasis of breast cancer cells.

  2. This study showed that ADAMTS1 (Montrer ADAMTS1 Protéines), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)

  3. Studies suggest that ADAM metallopeptidase (Montrer ECEL1 Protéines) with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target.

  4. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers

  5. Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia.

  6. study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases

  7. the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation.

  8. ADAMTS18 mutations promote growth, migration, and metastasis in melanoma

  9. ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM (Montrer ODZ1 Protéines) staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis.

  10. comparison of the effects of C-terminal truncation on the GAG-binding properties and aggrecanase (Montrer ADAMTS4 Protéines) activity of ADAMTS-5 (Montrer ADAMTS5 Protéines) relative to three other ADAMTS (Montrer ADAMTS13 Protéines) family members, ADAMTS-9, ADAMTS-16 and ADAMTS-18

Profil protéine ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18)

Profil protéine

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

Gene names and symbols associated with ADAMTS18

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 (Adamts18)
  • ADAM metallopeptidase with thrombospondin type 1 motif 18 (ADAMTS18)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 18 (Adamts18)
  • 9630038L21 Protéine
  • ADAMTS21 Protéine
  • E130314N14Rik Protéine
  • KNO2 Protéine
  • RGD1560118 Protéine

Protein level used designations for ADAMTS18

A disintegrin and metalloproteinase with thrombospondin motifs 18 , ADAM-TS 18 , ADAM-TS18 , ADAMTS-18 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21 , disintegrin and metalloprotease-like protein , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18

GENE ID SPECIES
208936 Mus musculus
100858277 Gallus gallus
170692 Homo sapiens
518395 Bos taurus
361412 Rattus norvegicus
101118979 Ovis aries
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