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Has both ADP-ribosyltransferase activity and thiol- dependent NAD(+) glycohydrolase activity..
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NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism.
ART2a is required for ADP-ribosylation of cell surface proteins
CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2.
Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect.
identify ART2.1 as a new candidate for linking autocrine/paracrine activation of inflammatory macrophages to the release of NAD, a critical intracellular metabolite
Extracellular nicotinamide adenine dinucleotide (NAD) acts via ART2.1 to regulate P2X7 purinergic receptor-dependent inflammatory responses in murine macrophages.
Has both ADP-ribosyltransferase activity and thiol- dependent NAD(+) glycohydrolase activity.
ADP-ribosyltransferase 2a pseudogene
, ADP-ribosyltransferase C2 and C3 toxin-like 2
, T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
, T-cell differentiation marker Rt6 homolog 1
, T-cell ecto-ADP-ribosyltransferase 1
, T-cell mono(ADP-ribosyl)transferase 1
, mono(ADP-ribosyl)transferase 2A