ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Protéines (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Anticorps (258) et ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ABCB1 5243 P08183
Rat ABCB1 ABCB1 170913  
Souris ABCB1 ABCB1 18669 P06795
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne

Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Protéines sur

Showing 5 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 70 to 75 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Insect cells (Sf9) Humain DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
Levure REACT_Entamoeba histolytica His tag   500 μg Connectez-vous pour afficher 60 to 71 Days

ABCB1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Protéines mieux référencés

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. dans Pharmaceutical research 2008 (PubMed)

Plus protéines pour ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) partenaires d'interaction

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. High ABCB1 expression is associated with vinorelbine resistance in lung cancer.

  2. The studied polymorphism in ABCB1 does not seem to affect the increased risk of multiple myeloma development.

  3. Dual luciferase activity assay demonstrated that ZNF139 inhibited transcriptional activities of miR-185's promoter in cells transfected with the reporter plasmid encompassing the upstream promoter region of miR-185 along with pcDNA-ZNF139. Our data reveal that ZNF139 might promote MDR gene MDR1/P-gp, MRP-1 and Bcl-2 by prohibiting miR-185

  4. The ABCB1 (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way

  5. MDR1 overexpression enhanced the viability and doxorubicin resistance of colon cancer cells.

  6. The carriage of ABCB1 mutant allele was not significantly associated with clopidogrel resistance risk.

  7. Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer.

  8. Our results suggested that the in vitro efficacy of anticancer drugs on the proliferation of colon cancer cells was significantly affected by P-gp in cancer cell lines abundantly expressing P-gp, accounting for 1.5% of cancer cell lines of all cancer types and 14.5% of colon cancer cell lines in the Cancer Cell Line Encyclopedia.

  9. Pgp expression was associated with an increase in the proinflammatory nature of CD8+ cells in bronchiolitis obliterans syndrome

  10. Genotype distribution was in Hardy-Weinberg equilibrium for all three ABCB1polymorphisms. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype, while heterozygous G/T was the most common genotype for c.2677G>T/A, mainly followed by G/G and T/T. 12 haplotypes were estimated from the three ABCB1 polymorphisms analyzed, with TTT the most frequent haplotype.

  11. This study aimed to explore the connection between the 10-hydroxycarbazepine concentration and genes such as ATP-binding cassette B1 (ABCB1), ATP-binding cassette C2 (ABCC2), UDP-glucuronosyltransferase-2B7 and sodium voltage-gated channel alpha subunit 2 (SCN2A), which participate in the antiepileptic function of oxcarbazepine

  12. Study identified that the miRNA149 contributes to the development of multidrug resistance within malignant mesothelioma cells by regulating the expression of MDR1.

  13. findings suggest that ABCA1 and ABCB1 proteins display similar arsenic resistance capabilities and possibly coordinate to promote arsenic resistance in AsRE cells

  14. Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer have been reported.

  15. ABCB1 polymorphism C3435T may contribute to potential life-threatening infections during paediatric acute lymophoblastic leukemia therapy, through glucocorticoid usage.

  16. TIPE2 sensitizes osteosarcoma cells to cis-platin through downregulation of MDR1 and may be a novel target in osteosarcoma therapy.

  17. The role of ABCB1 polymorphism as a prognostic marker for primary central nervous system lymphoma.

  18. ABCB1 C1236T, ABCB1 G2677 T/A genotype and BMI are probably the factors influencing the clinical efficacy of tacrolimus in treating patients with nephrotic syndrome .

  19. upregulation of ABCB1 can be considered as the crucial component of poor response to oxaliplatin which is likely controlled by miR-302c-5p.

  20. There was about 50% reduction on cells migration when MDR1 gene was down-regulated.

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

  2. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  3. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

  4. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  5. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  6. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

  7. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

  8. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

  9. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  10. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  11. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  12. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

  13. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

  14. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  15. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

  16. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

  17. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

  18. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

  19. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.

  20. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

Profil protéine ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1)

Profil protéine

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ABC20 Protéine
  • ABCB1 Protéine
  • CD243 Protéine
  • CLCS Protéine
  • GP170 Protéine
  • mdr Protéine
  • Mdr1 Protéine
  • Mdr1a Protéine
  • Mdr1b Protéine
  • p-gp Protéine
  • PGP1 Protéine
  • Pgy-1 Protéine
  • Pgy1 Protéine
  • xemdr Protéine

Protein level used designations for ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
Fournisseurs de qualité sélectionnés pour ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Protéines (ABCB1)
Avez-vous cherché autre chose?