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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Anticorps (39) et beaucoup plus de produits pour cette protéine.
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This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.
High MDR1 expression is associated with chemoresistance in ovarian cancer.
13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.
Haplotype analysis of ABCB1 (Montrer ABCB1 Protéines) conducted in patients with bullous pemphigoid (Montrer DST Protéines) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 (Montrer ABCB1 Protéines) expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 (Montrer ABCB1 Protéines) variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (Montrer STS Protéines). In addition, high MDR1 expression was significantly associated with local advances, as well as poor response to treatment.
These results indicated that MG132 reversed the MDR of hypopharyngeal carcinoma by downregulating Pgp/Pgp, and the underlying mechanism may be associated with the activation the of the JNK signaling pathway
This study elaborated a novel UCA1/miR (Montrer MLXIP Protéines)-129/ABCB1 (Montrer ABCB1 Protéines) regulatory axis underlying paclitaxel resistance of ovarian cancer cells.
this study shows that MDR1 (Montrer ABCB4 Protéines) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (Montrer ABCB4 Protéines) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (Montrer ABCB4 Protéines)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (Montrer ABCB4 Protéines) can affect the pulmonary kinetics of a subset of P-gp (Montrer ABCB4 Protéines) substrates.
Data suggest that the overexpression of P-gp (Montrer ABCB4 Protéines) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (Montrer ABCB4 Protéines), multi-drug resistance protein, MDR1 (Montrer ABCB4 Protéines)).Drugs with ER < 1 (Montrer MIER1 Protéines) almost do not bind the main binding cavity (MBC (Montrer CACNA1C Protéines)) of P-gp (Montrer ABCB4 Protéines).
conclusion, MDR1 (Montrer ABCB4 Protéines) and BCRP are expressed on apical membranes of the rodent placental SynT (Montrer STX1A Protéines)-II layer.
Mdr1 (Montrer ABCB4 Protéines) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (Montrer ABCB1 Protéines) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1