anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Anticorps

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ABCC6 Kits (20) et ABCC6 Protéines (16) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ABCC6 368 O95255
ABCC6 27421 Q9R1S7
ABCC6 81642 O88269
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Top anti-ABCC6 Anticorps sur anticorps-enligne.fr

Showing 10 out of 32 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Souris Inconjugué ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody. 100 μg Connectez-vous pour afficher 8 to 11 Days
$461.00
Détails
Humain Rat Inconjugué IHC (fro), IF, WB   1 mL Connectez-vous pour afficher 6 to 8 Days
$544.50
Détails
Humain Rat Inconjugué IHC (fro), FACS, IF, IHC (p), WB   1 mL Connectez-vous pour afficher 6 to 8 Days
$544.50
Détails
Souris Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded kidney tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$360.00
Détails
Humain Souris Inconjugué ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Rat Inconjugué ICC, IHC, IHC (fro), WB   1000 μL Connectez-vous pour afficher 7 to 9 Days
$969.83
Détails
Humain Rat Inconjugué ICC, IHC, WB   1000 μL Connectez-vous pour afficher 7 to 9 Days
$969.83
Détails
Humain Souris Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 7 to 9 Days
$537.17
Détails
Humain Souris Inconjugué ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Connectez-vous pour afficher 11 to 12 Days
$305.71
Détails
Humain Souris Inconjugué WB Western Blot analysis of ABCC6 expression in transfected 293T cell line by ABCC6 MaxPab polyclonal antibody.<br><br>Lane 1: ABCC6 transfected lysate(10.89 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails

anti-ABCC6 Anticorps mieux référencés

  1. Human Monoclonal ABCC6 Primary Antibody pour ELISA, WB - ABIN559916 : Pinckard, Sheehan, Arthur, Schreiber: Constitutive shedding of both p55 and p75 murine TNF receptors in vivo. dans Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre ABCC6 partenaires d’interaction

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. Serum levels of MRP8/MRP14 and MRP6 were up-regulated in patients with Graves' disease (GD) and Hashimoto's thyroiditis (HT). In addition, mRNA expression of MRP proteins in PBMCs and the thyroid gland was markedly elevated in these patients.

  2. High URG7 reduces the ER stress by decreasing the amount of unfolded proteins, by increasing both the total protein ubiquitination and the AKT (Montrer AKT1 Anticorps) activation and reducing Caspase 3 (Montrer CASP3 Anticorps) activation.

  3. Two compound heterozygous ABCC6 loss-of-function mutations, c.4182_4182delG (p.Lys1394Asnfs*9) and c.2900G > A (p.Trp967*), were found

  4. ABCC6 overexpression may also contribute to nilotinib and dasatinib resistance in vitro. With nilotinib and dasatinib now front line therapy options in the treatment of CML (Montrer BCR Anticorps), concomitant administration of ABCC6 inhibitors may present an attractive option to enhance TKI efficacy

  5. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6, ABCB1 (Montrer ABCB1 Anticorps) and CYP2C8 (Montrer CYP2C8 Anticorps) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  6. ABCC6 knockdown HepG2 cells show: 1) intracellular reductive stress; 2) cell cycle arrest in G1 phase; 3) upregulation of p21Cip p53 (Montrer TP53 Anticorps) independent; and 4) downregulation of lamin A/C (Montrer LMNA Anticorps). the absence of ABCC6 profoundly changes the HepG2 phenotype, suggesting that Pseudoxanthoma elasticum syndrome is a complex metabolic disease that is not exclusively related to the absence of pyrophosphate in the bloodstream.

  7. ABCC6 deficiency can be rescued by 4-phenylbutyrate therapy in a mouse model expressing human variants

  8. Biochemical and cell biological analyses demonstrate these mutations influence multiple steps in the biosynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly and trafficking. The differential impacts on local and global protein structure are consistent with hierarchical folding and assembly of ABCC6.

  9. The results suggest that a transmembrane domain is not required for transport function and that a cytosolic loop maintains ABCC6 in a targeting-competent state for the basolateral membrane and might be involved in regulating the nucleotide binding domains.

  10. The results of this study showed that mtDNA(atp6 (Montrer MT-ATP6 Anticorps)) variants were actively involved in schizophrenia in some families with maternal inheritance of this

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. abrogated ABCC6 function does cause alterations in the metabolic profile of the liver in accordance with PXE being a metabolic disease originating from liver disturbance

  2. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  3. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  4. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  5. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  6. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  7. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1 (Montrer ENPP1 Anticorps)(asj (Montrer ARSJ Anticorps)) mice.

  8. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  9. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  10. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

ABCC6 profil antigène

Profil protéine

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with ABCC6

  • ATP binding cassette subfamily C member 6 (ABCC6) anticorps
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6) anticorps
  • ATP binding cassette subfamily C member 6 (Abcc6) anticorps
  • ABC34 anticorps
  • Abcc1b anticorps
  • ARA anticorps
  • DCC anticorps
  • dyscalc anticorps
  • Dyscalc1 anticorps
  • EST349056 anticorps
  • GACI2 anticorps
  • MLP1 anticorps
  • MOAT-E anticorps
  • MOATE anticorps
  • Mrp6 anticorps
  • PXE anticorps
  • PXE1 anticorps
  • URG7 anticorps

Protein level used designations for ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

GENE ID SPECIES
368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour anti-ABCC6 (ABCC6) Anticorps
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