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ABHD2 encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. De plus, nous expédions Abhydrolase Domain Containing 2 Kits (13) et Abhydrolase Domain Containing 2 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Suppression of ABHD2 in OVCA420 cells increased phosphorylated p38 and ERK, platinum resistance, and side population cells (p<0.01, respectively). Conversely, overexpression of ABHD2 decreased resistance to anoikis (p<0.05) and the amount of phosphorylated p38 and ERK in OVCA420 and SKOV3 cells.
A mutant ABHD2 developed with alanine in place of Ser(207).
These results show that joint tests of main effects and gene-gene interaction reveal associations at some novel loci that were missed when considering main effects alone.
ABHD2 gene single nucleotide polymorphisms, such as rs12442260 contribute to chronic obstructive pulmonary disease susceptibility in the Chinese Han population.
ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progesterone-dependent lipid hydrolase by depleting the endocannabinoid 2-arachidonoylglycerol (2AG) from plasma membrane.
Patients with selective immunoglobulin (Ig)A deficiency have a highly significant increase of homozygousity of HS1.2 allele *1, with an increase of 2.6-fold; the HS1.2 polymorphism influences Ig seric production, but not IgG switch.
Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA.
LABH-2 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the testis
These findings suggest that derangement in alveolar phospholipid metabolism can induce emphysema, and that Abhd2 plays a critical role in maintaining lung structural integrity.
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.
abhydrolase domain-containing protein 2
, alpha/beta hydrolase domain containing protein 2
, lung alpha/beta hydrolase 2
, protein PHPS1-2
, abhydrolase domain containing 2
, abhydrolase domain-containing protein 2-A
, alpha/beta hydrolase fold protein
, 2-arachidonoylglycerol hydrolase
, Abhydrolase domain-containing protein 2-B
, abhydrolase domain-containing protein 2-B
, monoacylglycerol lipase ABHD2-B