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The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family.
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Human Polyclonal ACO2 Primary Antibody pour IHC (p), WB - ABIN388648
OConnell, Gannon, Doran, Ohlendieck: Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. dans International journal of molecular medicine 2007
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Human Polyclonal ACO2 Primary Antibody pour EIA, WB - ABIN357262
Geurts van Kessel, Westerveld, de Groot, Meera Khan, Hagemeijer: Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. dans Cytogenetics and cell genetics 1981
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Cow (Bovine) Polyclonal ACO2 Primary Antibody pour WB - ABIN2786627
Yu, Costello, Feng, Franklin: Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding. dans The Prostate 2006
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Human Polyclonal ACO2 Primary Antibody pour ICC, IF - ABIN4277666
Cantu, Fulton, Drechsel, Patel: Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂. dans Journal of neurochemistry 2011
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Human Monoclonal ACO2 Primary Antibody pour ELISA - ABIN513071
Lin, Brownsey, MacLeod: Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart. dans Cellular and molecular life sciences : CMLS 2009
Human Polyclonal ACO2 Primary Antibody pour ELISA, IHC - ABIN4277665
Bota, Davies: Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. dans Nature cell biology 2002
Cow (Bovine) Polyclonal ACO2 Primary Antibody pour IHC, WB - ABIN2786628
Scheving, Wittig, Heide, Albuquerque, Steger, Brandt, Tegeder: Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve. dans Journal of proteomics 2012
Human Polyclonal ACO2 Primary Antibody pour IHC (p), WB - ABIN391809
Dey, Guha, Alam, Goyal, Bindu, Pal, Maity, Mitra, Bandyopadhyay: Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. dans Free radical biology & medicine 2009
Human Polyclonal ACO2 Primary Antibody pour ICC, IF - ABIN442737
Tammineni, Anugula, Mohammed, Anjaneyulu, Larner, Sepuri: The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. dans The Journal of biological chemistry 2013
The identification of ACO1 (Montrer ACO1 Anticorps), ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers.
Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection
Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy.
immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men
Ogg1 (Montrer OGG1 Anticorps) chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells
Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression.
Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2.
these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter.
Lon (Montrer LONP1 Anticorps) protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase (Montrer ACO1 Anticorps) after mild oxidative modification, but that severe oxidation results in aconitase (Montrer ACO1 Anticorps) aggregation, which makes it a poor substrate for Lon (Montrer LONP1 Anticorps).
Activation of mitochondrial aconitase is acetylation-dependent.
IRP-1 (Montrer ACO1 Anticorps),-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development
aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation
study examined the sites and mechanisms of aconitase inactivation by peroxynitrite (ONOO-), a strong oxidant and nitrating agent readily formed from superoxide anion and nitric oxide generated by mitochondria
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
aconitate hydratase, mitochondrial
, mitochondrial aconitate hydratase
, aconitase 2, mitochondrial
, aconitate hydratase, mitochondrial-like
, citrate hydro-lyase
, mitochondrial aconitase (nuclear aco2 gene)
, heart aconitase