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ATF7IP is a multifunctional nuclear protein that associates with heterochromatin.
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Human Polyclonal MCAF1 Primary Antibody pour ICC, IF - ABIN4333001
Waterfield, Khan, Cortez, Fan, Metzger, Greer, Fasano, Martinez-Llordella, Pollack, Erle, Su, Anderson: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. dans Nature immunology 2014
Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB (Montrer PDGFRB Anticorps) fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB (Montrer PDGFRB Anticorps) exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB (Montrer PDGFRB Anticorps) fusion cDNA and its encoded chimeric protein, respectively.
these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 (Montrer SETDB1 Anticorps) abundance in the nucleus.
results indicate that ATF7IP does not directly modulate SETDB1 (Montrer SETDB1 Anticorps) catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.
these results indicate a critical role for MCAF1 in AP-1 (Montrer FOSB Anticorps)-dependent Rta (Montrer RBM9 Anticorps) activation of BZLF1 transcription.
We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 (Montrer DPEP1 Anticorps) protein complex in maintaining central tolerance
The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.
Genetic variants at ATF7IP and KLK2 (Montrer KLK2 Anticorps) contribute to the variance of %fPSA.
Studies identified three new susceptibility loci DMRT1 (Montrer DMRT1 Anticorps), TERT (Montrer TERT Anticorps) and ATF7IP associated with testicular germ cell cancer.
mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1 (Montrer SETDB1 Anticorps)
These data suggest that MBD1 (Montrer DPEP1 Anticorps).MCAF1.SETDB1 (Montrer SETDB1 Anticorps) complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF (Montrer CCL2 Anticorps)/AM family proteins in epigenetic control, and describe a new family member, MCAF2 (Montrer ATF7IP2 Anticorps).
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009
activating transcription factor 7-interacting protein 1
, activating transcription factor 7 interacting protein
, activating transcription factor 7-interacting protein 1-like
, ATF-interacting protein
, ATF7-interacting protein
, ATFa-associated modulator
, MBD1-containing chromatin associated factor
, MBD1-containing chromatin-associated factor 1
, ATFa-associated Modulator