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The protein encoded by ACSL6 catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor.
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ACSL6 drives acyl-CoA (Montrer GNPAT Anticorps) toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation
variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
The alternative fatty acid Gate-domain motifs are essential determinants for the activity of the human ACSL6 isoforms, which appear to act as homodimeric enzyme as well as in complex with other spliced forms.
The t(5;12)(q23-31;p13)translocation with ETV6 (Montrer ETV6 Anticorps)-ACSL6 genomic alteration rearrangement in polycythemia vera (Montrer IGF2BP3 Anticorps) patients was reported.
Analyses did not yield convincing evidence for associations of schizophrenia with ACSL6
Three ACSL6 spliced variants of a mutually exclusive exon pair are reported, they encode a slightly different short motif which contains a conserved structural domain, the fatty acid Gate domain.
haplotypes underlying the SPEC2 (Montrer CDC42SE2 Anticorps)/PDZ-GEF2 (Montrer RAPGEF6 Anticorps)/ACSL6 region are associated with schizophrenia
The acyl-coenzyme A (Montrer SOAT2 Anticorps) synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes.
ACSL6 is highly associated with schizophrenia and several haplotypes in this haploblock have about twofold to 10-fold increase in the affected subjects in Han Chinese.
Long-chain acyl-CoA synthetase (Montrer Acsl3 Anticorps) expressed in brain participates in neuronal cell proliferation.
Acsl6 promoter 1 (mAcsl6_pr1) region has a negative regulatory function
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.
fatty-acid-Coenzyme A ligase, long-chain 6
, long fatty acyl-CoA synthetase 2
, long-chain-fatty-acid--CoA ligase 6
, acyl-CoA synthetase long-chain family member 6
, acyl-CoA synthetase long-chain family member 6, isoform 2
, long-chain-fatty-acid--CoA ligase 6-like
, LACS 6
, fatty acid Coenzyme A ligase, long chain 6
, long-chain acyl-CoA synthetase 6
, long-chain-fatty-acid--CoA ligase, brain isozyme
, similar to Long-chain-fatty-acid--CoA ligase 6 (Long-chain acyl-CoA synthetase 6) (LACS 6)