anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Anticorps

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

1. Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT (Montrer ITK Anticorps) via Akt2 (Montrer AKT2 Anticorps) phosphorylation.

2. APPL1 positively mediated leptin (Montrer LEP Anticorps) signaling.

3. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

4. Results indicate that persistent rab5 (Montrer RAB5A Anticorps) overactivation through beta-cleaved carboxy-terminal fragment of APP (Montrer APP Anticorps)-APPL1 interactions constitutes a novel APP (Montrer APP Anticorps)-dependent pathogenic pathway in Alzheimer's disease

5. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

6. Low expression of APPL1 is associated with metastasis in prostate cancer.

7. APPL1 endosomes represent a distinct population of Rab5 (Montrer RAB5A Anticorps)-positive sorting endosomes.

8. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (Montrer TSC2 Anticorps)

9. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

10. A role for APPL1 in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon (Montrer IKBKE Anticorps) activation in macrophages.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

1. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (Montrer PRKCZ Anticorps), as well as its functional interaction with both PP2A (Montrer PPP2R2B Anticorps) and myosin IIa.

2. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

3. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (Montrer TLR4 Anticorps)-induced signaling, transcription, and cytokine secretion.

4. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Anticorps)-induced Akt (Montrer AKT1 Anticorps) activation, migration, and invasion.

5. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (Montrer PRKAA1 Anticorps) signaling.

6. A role for APPL1 in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon (Montrer IKBKE Anticorps) activation in macrophages.

7. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

8. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

9. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (Montrer INS Anticorps) sensitivity.

10. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (Montrer INS Anticorps) resistance and improves adipoR1 (Montrer ADIPOR1 Anticorps)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue