anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Anticorps

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 97 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL 2 to 3 Days
$289.00
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg 6 to 7 Days
$429.84
Détails
Humain Chèvre Inconjugué ELISA, WB Antibody (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-APPL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other for ... 100 μL 11 to 14 Days
$727.83
Détails
Boeuf (Vache) Chèvre Inconjugué WB   0.1 mg 4 to 8 Days
$462.00
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Disponible
$363.46
Détails
Boeuf (Vache) Chèvre Inconjugué ELISA, WB 100 μg 11 to 14 Days
$610.50
Détails
Souris Lapin Inconjugué ICC, IF, IHC (p), IP, WB 50 μL 7 to 8 Days
$510.24
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from A549 cells, using APPL1 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275052 staining  A549 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells,using APPL1 antibody. 100 μL 11 to 13 Days
$366.77
Détails

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps mieux référencés

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody pour ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. dans Oncogene 1999 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal APPL1 Primary Antibody pour ELISA, WB - ABIN547835 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. dans Nature cell biology 2006 (PubMed)

Plus d’anticorps contre Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 partenaires d’interaction

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT via Akt2 phosphorylation.

  2. APPL1 positively mediated leptin signaling.

  3. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  4. Results indicate that persistent rab5 overactivation through beta-cleaved carboxy-terminal fragment of APP-APPL1 interactions constitutes a novel APP-dependent pathogenic pathway in Alzheimer's disease

  5. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  6. Low expression of APPL1 is associated with metastasis in prostate cancer.

  7. APPL1 endosomes represent a distinct population of Rab5-positive sorting endosomes.

  8. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

  9. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  10. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.

  11. ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  12. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

  13. APPL1 is a positive regulator of Dvl2-dependent transcriptional activity of AP-1.

  14. It concludes that APPL1(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin.

  15. The activated EGF receptor enters distinct sub-populations of SNX15- and APPL1-labelled peripheral endocytic vesicles.

  16. C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.

  17. TRAF6-mediated ubiquitination of APPL1 is a vital step for the hepatic actions of insulin through modulation of membrane trafficking and activity of Akt.

  18. Rab5a and APPL1 are overexpressed in breast cancer, and are positively correlated with the HER-2 expression.

  19. neurons with APPL1-positive granules were restricted to the CA1 area and subiculum, areas associated with hippocampal vulnerability, suggesting a possible link between the perisomatic accumulation of APPL1 and Alzheimer's disease.

  20. APPL1 regulates basal NF-kappaB activity by modulating the stability of NIK, which affects the activation of p65.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 may be a key regulator of insulin resistance in skeletal muscle, and Resistance training may be an important physiological treatment increasing APPL1 expression, which is attenuated in T2 Diabetes.

  2. This study reports an alternative splicing variant of APPL1 (APPL1sv) that is highly expressed in mouse liver, pancreas, and spleen tissues. The expression levels of APPL1sv in liver tissues were enhanced in a mouse model of obesity and diabetic dyslipidemia (i.e. db/db mice) and reduced in calorie-restricted mice compared with ad libitum-fed mice.

  3. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A and myosin IIa.

  4. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

  5. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4-induced signaling, transcription, and cytokine secretion.

  6. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF-induced Akt activation, migration, and invasion.

  7. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK signaling.

  8. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.

  9. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

  10. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  11. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin sensitivity.

  12. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  13. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt cascade in neurons.

  14. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin resistance to beta-cell dysfunction in type 2 diabetes.

  15. Endurance training was able to increase APPL1 expression.

  16. APPL1 plays a key role in coordinating the vasodilator and vasoconstrictor effects of insulin by modulating Akt-dependent NO production and ERK1/2-mediated ET-1 secretion in the endothelium.

  17. Data found that the inhibitory effect of adiponectin on osteoclasts was induced by APPL1-mediated down-regulation of Akt1 activity.

  18. Appl1 is dispensable for Akt signaling in vivo and T-cell differentiation.

  19. The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt.

  20. Appl proteins are required for HGF-induced cell survival and migration via activation of Akt

Pig (Porcine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. This study showed that high levels of FSHR, AKT2, and APPL1 were expressed in the ovaries of high prolific breed pigs.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) profil antigène

Profil protéine

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) anticorps
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) anticorps
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Appl1) anticorps
  • 2900057D21Rik anticorps
  • 7330406P05Rik anticorps
  • AI585782 anticorps
  • APPL anticorps
  • AW209077 anticorps
  • BB022931 anticorps
  • C88264 anticorps
  • DIP13 anticorps
  • DIP13alpha anticorps
  • RGD1309388 anticorps

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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