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The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal APPL2 Primary Antibody pour IF, WB - ABIN527414
Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. dans The Journal of endocrinology 2011
Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 (Montrer APLP2 Anticorps) gene provides a putative colorectal neoplasm progression index.
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
ATM (Montrer ATM Anticorps) is the central modulator of APPL (Montrer APPL1 Anticorps)-mediated effects on radiosensitivity and DNA repair.
It concludes that APPL2 (Montrer APLP2 Anticorps)(PH) binding to BAR domain and Reptin (Montrer RUVBL2 Anticorps) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (Montrer RUVBL2 Anticorps).
C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.
Data indicate that a high level of APPL2 (Montrer APLP2 Anticorps) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.
analysis of APPL1 (Montrer APPL1 Anticorps) and APPL2 (Montrer APLP2 Anticorps) proteins and their interaction with Rab (Montrer HRB Anticorps)
Genetic variation(s) in APPL1 (Montrer APPL1 Anticorps)/2 may be associated with CAD (Montrer CAD Anticorps) risk in T2DM in Chinese population.
Data suggest that although annexin A2 (Montrer ANXA2 Anticorps) is not an exclusive marker of APPL1 (Montrer APPL1 Anticorps)/2 endosomes, it has an important function in membrane recruitment of APPL (Montrer APPL1 Anticorps) proteins, acting in parallel to Rab5 (Montrer RAB5A Anticorps).
significant fluorescence resonance energy transfer between APPL (Montrer APPL1 Anticorps) minimal BAR domain FRET pairs
Here we establish potential roles for APPL1 (Montrer APPL1 Anticorps) and 2 signaling adaptors as regulators of LPS/TLR4 (Montrer TLR4 Anticorps)-induced signaling, transcription, and cytokine secretion.
Appl1 (Montrer APPL1 Anticorps)/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Anticorps)-induced Akt (Montrer AKT1 Anticorps) activation, migration, and invasion.
Rab31 (Montrer RAB31 Anticorps), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (Montrer AKT1 Anticorps) signaling in macrophages.
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
DCC-interacting protein 13-beta
, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
, amyloid beta (A4) precursor-like protein 2
, DIP13 beta
, adapter protein containing PH domain, PTB domain and leucine zipper motif 2
, Dip3 beta