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Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.
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Chlamydomonas reinhardtii (C. reinhardtii) Polyclonal AOX1 Primary Antibody pour WB - ABIN125886
Liu, Li, Wang, Xing: Overexpression of ALTERNATIVE OXIDASE1a alleviates mitochondria-dependent programmed cell death induced by aluminium phytotoxicity in Arabidopsis. dans Journal of experimental botany 2014
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AOX1 SNPs exist in which the base-pair exchange of the SNP leads to loss of enzyme activity.
ten novel single nucleotide polymorphisms resulting in amino acid exchanges in proximity to the FAD (Montrer BRCA2 Anticorps) site of hAOX1 (Montrer HAO1 Anticorps), were characterized.
Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1), NAT2 (N-acetyltransferase 2 (Montrer NAT2 Anticorps)), AADAC (arylacetamide deacetylase (Montrer AADAC Anticorps)), and CYP3A4 (cytochrome P450 3A4 (Montrer CYP3A4 Anticorps)).
Data suggest that substrate specificity of AOX1 includes GDC (Montrer SLC25A16 Anticorps)-0834, an inhibitor of Bruton's tyrosine kinase (Montrer IBTK Anticorps) with potential non-steroidal anti-inflammatory agent activity; in liver cytosol, hydrolysis of GDC (Montrer SLC25A16 Anticorps)-0834 is primarily due to AOX1.
Methotrexate is poorly metabolized by human AOX1, in contrast to rabbit.
These results supported the possibility that XO/XD (Montrer XDH Anticorps) and AO can contribute to nitric oxide generation.
Several donors have a normal AOX1 protein level.
High AOX1 methylation was associated with biochemical recurrence in prostate cancer.
The physiological role of AOX1 remains unclear, but it is known that thiopurines belong to its substrates; AOX1 contributes to azathioprine catabolism.
hydralazine, at a concentration of 25 to 50 muM, can be used in human hepatocyte incubations to estimate the contribution of aldehyde oxidase to the hepatic clearance of drugs and other compounds.
findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2
These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism.
In addition to their aldehyde oxidation activity, AAO1 and AAO3 were found to exhibit NADH oxidase activity, which likewise is associated with the production of superoxide anions.
Data show that alternative oxidase (AOX) fully restores ATP levels and prevents dopaminergic neurodegeneration.
Amino acid substitution experiments reveal structural aspects of substrate specificity of AOX1.
Exposure of C. reinhardtii to nitric oxide (NO) resulted in the up-regulation of AOX1 expression and an increased AOX1 protein. Furthermore, NO-treated C. reinhardtii cells displayed the enhanced AOX1 capacity. We also clearly demonstrated that AOX1 can function in C. reinhardtii when the cytochrome oxidase became inhibited by NO.
Characterization of heat-induced AOX1 regulation in the green alga C. reinhardtii provides a framework for a more complete understanding of the function of this conserved protein.
in nitrate-grown cells, AOX (Montrer ACOX1 Anticorps) may play a dual role: (1) lowering the ubiquinone pool reduction level and (2) permitting the export of mitochondrial reducing power under the form of malate for nitrate and nitrite reduction
In the present work, we have isolated by RNA interference and characterized at the functional and the proteomic levels a Chlamydomonas reinhardtii strain devoid of the mitochondrial alternative oxidase 1 (AOX1).
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.
, aldehyde oxidase 2
, retinal oxidase
, aldehyde oxidase (female form)
, aldehyde oxidase 1