anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Anticorps

The protein encoded by ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). De plus, nous expédions ASPSCR1 Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ASPSCR1 691026  
ASPSCR1 79058 Q9BZE9
ASPSCR1 68938 Q8VBT9
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Top anti-ASPSCR1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 113 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, WB ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35µg/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of ASPSCR1/TUG Antibody (C-term) in Hela cell line lysates (35ug/lane). ASPSCR1 (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cell lines, using ASPSCR1 antibody. Immunohistochemistry of paraffin-embedded rat kidney using ASPSCR1 antibody at dilution of 1:100 (x400 lens). 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IF, IHC, WB Western blot analysis of extracts of various cell lines, using ASPSCR1 antibody. Immunohistochemistry of paraffin-embedded rat kidney using ASPSCR1 antibody. 200 μL 12 to 14 Days
$438.90
Détails
Souris Souris Inconjugué ELISA, WB   100 μL Disponible
$546.20
Détails
Humain Lapin Inconjugué WB Western blot analysis in A2058 cell line lysates (35ug/lane). Western blot analysis of ASPSCR1 using rabbit polyclonal ASPSCR1 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using ASPSCR1 antibody (ABIN5975297) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat kidney using ASPSCR1 antibody (ABIN5975297) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Détails
Humain Lapin Inconjugué FACS, IHC, IHC (p), WB Human, Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE) Human, Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE) 200 μL 11 to 14 Days
$484.00
Détails

anti-ASPSCR1 Anticorps mieux référencés

  1. Mouse (Murine) Monoclonal ASPSCR1 Primary Antibody pour ELISA, WB - ABIN537080 : Bogan, Hendon, McKee, Tsao, Lodish: Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. dans Nature 2003 (PubMed)

Plus d’anticorps contre ASPSCR1 partenaires d’interaction

Human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. By morphologic, immunohistochemical, genetic, and prognostic similarities, alveolar soft-part sarcoma with the ASPSCR1-TFE3 gene fusion has a closer relationship with Xp11 neoplasm with melanocytic differentiation/TFE3 rearrangement-associated PEComa/melanotic Xp11 translocation renal cancer/melanotic Xp11 neoplasm

  2. ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation.

  3. These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression.

  4. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.

  5. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  6. ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain.

  7. Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells.

  8. Promotes methylation of VCP by METTL21D

  9. Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types.

  10. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique.

  11. Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma.

  12. Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma

Mouse (Murine) Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. Insulin acts through TUG proteins to control IRAP targeting, similar to GLUT4; the activity of vasopressin, an IRAP substrate, is reduced in mice with disrupted TUG action in muscle.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. Data indicate that insulin stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)) to translocate GLUT4 in muscle.

  4. Data suggest a model whereby insulin stimulates TUG cleavage to liberate GLUT4 storage vesicles from the Golgi matrix, which promotes GLUT4 translocation to the cell surface and enhances glucose uptake.

  5. TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether

  6. insulin-stimulated dissociation of TUG and GLUT4 as an important action by which insulin stimulates glucose uptake.

ASPSCR1 profil antigène

Profil protéine

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\;17)(p11\;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Gene names and symbols associated with ASPSCR1

  • ASPSCR1, UBX domain containing tether for SLC2A4 (ASPSCR1) anticorps
  • alveolar soft part sarcoma chromosome region, candidate 1 S homeolog (aspscr1.S) anticorps
  • ASPSCR1, UBX domain containing tether for SLC2A4 (Aspscr1) anticorps
  • alveolar soft part sarcoma chromosome region, candidate 1 (aspscr1) anticorps
  • alveolar soft part sarcoma chromosome region, candidate 1 (Bm1_55980) anticorps
  • alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1) anticorps
  • 1190006K01Rik anticorps
  • ASPC anticorps
  • ASPCR1 anticorps
  • ASPL anticorps
  • ASPS anticorps
  • RCC17 anticorps
  • TUG anticorps
  • UBXD9 anticorps
  • UBXN9 anticorps

Protein level used designations for ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1 , hypothetical protein LOC495145 , tether containing UBX domain for GLUT4 , UBX domain protein 9 , UBX domain-containing protein 9 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein , alveolar soft part sarcoma locus , renal cell carcinoma gene on chromosome 17 , renal cell carcinoma, papillary, 17 , renal papillary cell carcinoma protein 17 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog , tether, containing a UBX domain, for GLUT4

GENE ID SPECIES
417384 Gallus gallus
495145 Xenopus laevis
691026 Rattus norvegicus
733865 Xenopus (Silurana) tropicalis
6106077 Brugia malayi
515670 Bos taurus
79058 Homo sapiens
68938 Mus musculus
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