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may play a role in mineralization of tooth enamel matrix [RGD, Feb 2006]..
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Human AMELX Kit ELISA pour Sandwich ELISA - ABIN1118161
Ma, Luo, Wu, Chen, Kou, Wang: Circulation levels of acute phase proteins in patients with Takayasu arteritis. dans Journal of vascular surgery 2010
The calcium level was associated with genetic variations in AMELX, AMNB and ESRRB. AMELX and AMNB are involved in enamel mineralization. Mutations in both these genes are responsible for the amelogenesis imperfecta phenotype (OMIN), which supports their link with enamel alterations as well as enamel mineralization.
a single-nucleotide polymorphism in the amelogenin gene using amplified product-length polymorphisms in combination with sex-determining region Y (Montrer SRY Kits ELISA) analysis, is reported.
Full-length amelogenin may have a negative mitogenic impact on human dental pulp stem cells.
suggestive overrepresentation of TT genotype of amelogenin marker in cases w/severe erosion when compared to no dentine erosion. Amelogenin also associated with severe erosion in recessive model; TT genotype significantly more frequent in affected group
Studies indicate that a single point mutation (41Pro-->Thr (Montrer TRH Kits ELISA)) in the amelogenin gene causes severe dental enamel malformation known as amelogenesis imperfect.
silent mutation in exon 4 of AMELX gene. generating and characterizing transgenic animal model, alteration of the ratio and quantity of the developmentally conserved alternative splicing repertoire of AMELX caused defects in enamel matrix mineralization.
Conversion to amelogenin expressing dental epithelial cells involved an up-regulation of the stem cell marker Sox2 (Montrer SOX2 Kits ELISA) and proliferation genes and decreased expression of mesenchymal markers
the interaction of amelogenin with Grp78/Bip (Montrer HSPA5 Kits ELISA) contributed to cell proliferation, rather than correlate with the osteogenic differentiation
demonstrate the presence of copy number variations in regions containing 9 of the 13 CODIS(Combined DNA Index System) short tandem repeat(STR (Montrer STATH Kits ELISA)) and AMELX/Y loci
Associations between TFIP11 (Montrer TFIP11 Kits ELISA) (p=0.02), ENAM (Montrer ENAM Kits ELISA) (p=0.00001), and AMELX (p=0.01) could be seen with caries independent of having MIH or genomic DNA copies of Streptococcus mutans detected by real time PCR in the Brazilian sample.
MMP20 (Montrer MMP20 Kits ELISA) in a common ancestor of tetrapods might have been recruited for the processing of AMEL and conserved over 350 million years of evolution.
The maxillary incisors of Amelx-/- mutants indicated the increase of the frequency and number of labial (Montrer LAT2 Kits ELISA) grooves with aging.
Results provide evidence that all three regions of amelogenin (N-terminus, C-terminus, central core) are required for enamel formation and structure.
an involvement of LRAP in lipid-raft-dependent signaling pathways are mediated by flotillin-1 (Montrer FLOT1 Kits ELISA).
transcriptional activation of Amelx was associated with enhanced osteogenic differentiation, especially in the early stage of biomineralization
LRAP is primarily monomeric in solution, suggesting that the monomeric species may be an important functional form of some amelogenins.
AMELX may function as a growth factor-like molecules solubilized in the aqueous microenvironment. In jaws (Montrer IMPAD1 Kits ELISA), it might play some role in bone physiology through autocrine/paracrine pathways, particularly during development and stress-induced remodeling.
temporal/spatial localization of amelogenins with exon4 peptide and functional differences in HAP binding suggests unique properties of amelogenins containing exon4 cause specific enhancement of biomineralization of early-formed HAP at maturation stage
Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.
may play a role in mineralization of tooth enamel matrix
amelogenesis imperfecta 1
, amelogenin (X chromosome, amelogenesis imperfecta 1)
, amelogenin (amelogenesis imperfecta 1, X-linked)
, amelogenin, X isoform
, amelogenin (X chromosome)
, amelogenin, X-linked
, amelogenin X chromosome
, enamel matrix protein
, leucine-rich amelogenin peptide
, X-chromosomal amelogenin
, class I amelogenin