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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. De plus, nous expédions Amiloride-Sensitive Cation Channel 2, Neuronal Anticorps (120) et Amiloride-Sensitive Cation Channel 2, Neuronal Protéines (7) et beaucoup plus de produits pour cette protéine.
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (Montrer ACCN1 Kits ELISA) differential properties; ACCN1 and ACCN3 (Montrer ACCN3 Kits ELISA) genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.
ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (Montrer ACCN1 Kits ELISA), and acid-sensing ion channel 3 (Montrer ACCN3 Kits ELISA) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (Montrer CA2 Kits ELISA)+)/PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (Montrer FAM126A Kits ELISA)).
Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.
The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (Montrer ADORA2A Kits ELISA) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian
analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel
Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The
Putative GABAA (Montrer GABRg1 Kits ELISA) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin (Montrer ACTN1 Kits ELISA) was determined in glioma tumor cells.
ASIC1a opening is accompanied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu (Montrer DCTN1 Kits ELISA)-235 relative to the knuckle helix.
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (Montrer PTPN2 Kits ELISA) Model of Parkinson Disease
The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be
nonselective cation channels ( channels consist of at least one alpha-ENaC (Montrer SCNN1A Kits ELISA) and one or more acid-sensing ion channel 1a (ASIC1a) proteins.
ASIC1a is an important mediator of AHR (Montrer AHR Kits ELISA).
Ca(2 (Montrer CA2 Kits ELISA)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (Montrer EDN1 Kits ELISA)-induced NFATc3 (Montrer NFATC3 Kits ELISA) nuclear import and 2) the scaffolding protein PICK1 (Montrer PICK1 Kits ELISA) is necessary for NFATc3 (Montrer NFATC3 Kits ELISA) nuclear import.
This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (Montrer GRIN1 Kits ELISA) (mGlu) receptor-induced increase in action potential firing.
the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a (Montrer ACCN1 Kits ELISA) subunits, but not ASIC1b, ASIC3 (Montrer ACCN3 Kits ELISA) subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
Studies with ASIC1a-ASIC2a (Montrer ACCN1 Kits ELISA) chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys (Montrer DNAJC5 Kits ELISA) residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a, ASIC2a (Montrer ACCN1 Kits ELISA), and ASIC2b, was investigated.
This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
amiloride-sensitive cation channel 2, neuronal
, amiloride-sensitive cation channel 1, neuronal
, Amiloride-sensitive cation channel 2, neuronal
, acid-sensing ion channel 1
, brain sodium channel 2
, proton gated cation channel ASIC1
, Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1a protein
, acid sensing ion channel
, degenerin 2