anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) Anticorps

ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily.

afficher tous les anticorps Gène GeneID UniProt
Anti-Rat ACCN3 ACCN3 286920 O35240
Anti-Humain ACCN3 ACCN3 9311 Q9UHC3
Anti-Souris ACCN3 ACCN3 171209 Q6X1Y6
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Top anti-Amiloride-Sensitive Cation Channel 3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 59 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Human kidney WB Suggested Anti-ACCN3 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Kidney 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$493.17
Détails
Humain Lapin Inconjugué WB Anti-ASIC3 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Rat Testis Tissue Lysate Lane 3: U87 Cell Lysate Lane 4: NEURO Cell Lysate Lane 5: SMMC Cell Lysate Western blot analysis of ASIC3 using anti- ASIC3 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: Rat Brain Tissue Lysate,  Lane 2: Rat Testis Tissue Lysate,  Lane 3: U87 Cell Lysate,  Lane 4: NEURO Cell Lysate,  Lane 5: SMMC Cell Lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- ASIC3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for ASIC3 at approximately 69KD. The expected band size for ASIC3 is at 58KD. 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Humain Lapin Inconjugué WB ACCN3 Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ACCN3 antibody detected the ACCN3 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Connectez-vous pour afficher 16 Days
$181.73
Détails
Humain Lapin Inconjugué IHC, IHC (p) Immunohistochemistry-Paraffin: Amiloride-sensitive cation channel 3 Antibody [NBP2-14322] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells. Immunohistochemistry-Paraffin: Amiloride-sensitive cation channel 3 Antibody  - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Rat Cobaye Inconjugué ICC, IHC   50 μL Connectez-vous pour afficher 7 to 9 Days
$669.17
Détails
Humain Lapin Inconjugué IHC, WB ACCN3 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X ACCN3 antibody used at 2.5 ug/ml to detect target protein. 100 μg Connectez-vous pour afficher 2 to 3 Days
$388.93
Détails
Humain Lapin Inconjugué IHC, ELISA, WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$446.88
Détails
Rat Cobaye Inconjugué ICC, IHC (fro), IF, IHC Immunocytochemistry/Immunofluorescence: Amiloride-sensitive cation channel 3 Antibody [ABIN250611] - ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). A and D, normal and CF human lung sections imaged following incubation with the mixture of anti-ASIC3 antibody and immunopeptide. Shown are normal (B) and CF (E) alveolar structures at a small magnification. ASIC3 expression was detected in both types I and II alveolar cells. Shown are normal (C) and CF (F) alveolar structures at a large magnification. Scale bars equal 10 um in A, B, D, and E and 20 um in C and F. 0.05 mL Connectez-vous pour afficher 8 to 11 Days
$345.00
Détails

Plus d’anticorps contre Amiloride-Sensitive Cation Channel 3 partenaires d’interaction

Horse (Equine) Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (Montrer ACCN1 Anticorps) differential properties; ACCN1 (Montrer ACCN2 Anticorps) and ACCN3 genes have an ubiquitous expression but ACCN1 (Montrer ACCN2 Anticorps) is more highly expressed in the spinal cord.

Human Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. Acidic pH resulted in an increase in ASIC-3 expressionin the discs of paitents with intervertebral disc degeneration.

  2. the data demonstrate a functional link between ASICs and [Ca(2 (Montrer CA2 Anticorps)+)]i/RhoA (Montrer RHOA Anticorps) pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.

  3. The results show that acid-sensing ion channel 1 (Montrer ACCN2 Anticorps), acid-sensing ion channel 2 (Montrer ACCN1 Anticorps), and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel (Montrer ACCN2 Anticorps)-like currents were elicited by extracellular acid stimuli.

  4. Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing.

  5. These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling.

  6. Sea (Montrer Slc25a1 Anticorps) anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.

  7. Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms.

  8. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation.

  9. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95 (Montrer DLG4 Anticorps).

  10. Lignan from thyme possesses inhibitory effect on ASIC3 channel current.

Mouse (Murine) Amiloride-Sensitive Cation Channel 3 (ACCN3) interaction partners

  1. acid-sensing ion channel 3, activated by concomitant acid and certain pruritogens, constitute a novel signaling pathway that counteracts itch tachyphylaxis to successive pruritogenic stimulation.

  2. a small conopeptide of only four amino acids from the venom of Conus textile that strongly potentiated currents of ASIC3, which has a specific role in the pain pathway. This peptide, RPRFamide, belongs to the subgroup of cono-RFamides.

  3. High ASIC3 expression is associated with Bone Pain Induced by Multiple Myeloma.

  4. This study suggested that the macrophage- and neutrophil-produced IL1beta (Montrer IL1B Anticorps) in the muscles during I/R activates enhanced IL1r1 (Montrer IL1RN Anticorps) in muscle afferents increase expression of ASIC3 possibly via JNK (Montrer MAPK8 Anticorps) activation.

  5. segmental analgesia of electroacupuncture-induced analgesia (EA) with lower intensity is partially mediated by ASIC3 receptor on Abeta (Montrer APP Anticorps)-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 (Montrer TRPV1 Anticorps) receptor on Adelta- and C-fibers

  6. the potentiation of ASICs by quinine depends on the presence of the ASIC1a (Montrer ACCN2 Anticorps), ASIC2a (Montrer ACCN1 Anticorps) subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a (Montrer ACCN2 Anticorps) that are involved in the modulation of ASICs by pHi.

  7. fatigue reduces pH in muscle that subsequently activates ASIC3 on macrophages to enhance hyperalgesia to muscle insult.

  8. ASIC3 is critical for scratching behavior and pathological changes in chronic itch.

  9. Data suggest that activation of acid-sensing ion channel 3 (ASIC3) on fibroblast-like synoviocytes (FLS) by acidic pH from an inflamed joint could limit synovial proliferation resulting in reduced inflammatory mediators and subsequent joint damage.

  10. we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli.

Amiloride-Sensitive Cation Channel 3 (ACCN3) profil antigène

Profil protéine

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN3

  • amiloride-sensitive cation channel 3 (ACCN3) anticorps
  • acid sensing ion channel subunit 3 (ASIC3) anticorps
  • acid sensing ion channel subunit 3 (Asic3) anticorps
  • acid-sensing (proton-gated) ion channel 3 (Asic3) anticorps
  • Accn3 anticorps
  • AW742291 anticorps
  • DRASIC anticorps
  • SLNAC1 anticorps
  • TNAC1 anticorps

Protein level used designations for ACCN3

amiloride-sensitive cation channel 3 , amiloride-sensitive cation channel 3-like , DRASIC , acid sensing ion channel 3 , acid-sensing ion channel 3 , dorsal root ASIC , proton gated cation channel DRASIC , amiloride-sensitive cation channel 3, testis , modulatory subunit of ASIC2a , neuronal amiloride-sensitive cation channel 3 , proton-gated cation channel subunit , testis sodium channel 1

GENE ID SPECIES
429486 Gallus gallus
100063408 Equus caballus
100350503 Oryctolagus cuniculus
100442058 Pongo abelii
286920 Rattus norvegicus
9311 Homo sapiens
171209 Mus musculus
482801 Canis lupus familiaris
789132 Bos taurus
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