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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. De plus, nous expédions Angiotensin II Receptor-Associated Protein Protéines (4) et Angiotensin II Receptor-Associated Protein Kits (3) et beaucoup plus de produits pour cette protéine.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (Montrer AGTR1 Anticorps), plays a protective role against the development of systemic insulin (Montrer INS Anticorps) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (Montrer PITPNA Anticorps) RdgBbeta (Montrer PITPNC1 Anticorps) binds 14-3-3 (Montrer YWHAQ Anticorps) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (Montrer CSF2 Anticorps) angiotensin II, ACE (Montrer ACE Anticorps), and ACE2 (Montrer ACE2 Anticorps) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (Montrer AQP4 Anticorps) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (Montrer AGTR1 Anticorps)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (Montrer ARAP1 Anticorps), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (Montrer EPHA3 Anticorps)-293 cells
CAML (Montrer CAMLG Anticorps) is an important signal transducer for the actions of Ang II (Montrer AGT Anticorps) in regulating the calcineurin-NFAT (Montrer NFATC1 Anticorps) pathway and the interaction of CAML (Montrer CAMLG Anticorps) with ATRAP may mediate the Ang II (Montrer AGT Anticorps) actions in vascular physiology
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (Montrer TGFB1 Anticorps) of the cardiac Ca(2+)-ATPase SERCA2a (Montrer CA-P60A Anticorps). Suggest that Atrap enhances the activity of SERCA2a (Montrer ATP2A2 Anticorps) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R (Montrer P2RY6 Anticorps) heterodimers with age may increase the likelihood of hypertension induced by Ang II (Montrer AGT Anticorps).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
The inhibition of degradation of angiotensin II type 1 receptor (Montrer AGTR1 Anticorps)-associated protein (Montrer BCAP31 Anticorps) (ATRAP) and inactivation of AT1R-mediated p38 MAPK (Montrer MAPK14 Anticorps) and STAT3 (Montrer STAT3 Anticorps) signaling pathways, are involved cardiac hypertrophy.
Activation of aortic vascular ATRAP partially inhibits the Nox4 (Montrer NOX4 Anticorps)/p22(phox (Montrer CYBA Anticorps))-ROS (Montrer ROS1 Anticorps)-p38MAPK (Montrer MAPK14 Anticorps)/JNK (Montrer MAPK8 Anticorps) pathway and pathological aortic hypertrophy provoked by Ang II (Montrer AGT Anticorps)-mediated hypertension.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I