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APOBEC3B is a member of the cytidine deaminase gene family. De plus, nous expédions APOBEC3B Protéines (5) et beaucoup plus de produits pour cette protéine.
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results suggest that B-Myb (Montrer MYBL2 Anticorps)-A3B (Montrer SGCB Anticorps) contributes to DNA damage and could be targeted by inhibiting EGF receptor (Montrer EGFR Anticorps).
APOBEC3A (Montrer APOBEC3A Anticorps)/B deletion was associated with young age at diagnosis among the cancer cases for both cancer forms (lung cancer: P = 0.02; dominant model and prostate cancer
These studies combine to indicate that APOBEC3B promotes drug resistance in breast cancer and that inhibiting APOBEC3B-dependent tumor evolvability may be an effective strategy to improve efficacies of targeted cancer therapies.
Our results provide evidence that APOBEC3B can interact with HBV core protein and edit HBV DNAs during reverse transcription. These data suggest that APOBEC3B exerts multifaceted antiviral effects against HBV.
review of current understanding of APOBEC3A (Montrer APOBEC3A Anticorps) and APOBEC3B biology in human papillomavirus Infection restriction, evolution, and associated cancer mutagenesis
This study found that A3B (Montrer SGCB Anticorps) C-terminal domain shows higher activity toward its target sequence in short ssDNA and efficiently deaminates a target sequence located near the center of ssDNA.
Data show that the larger oligomeric state of APOBEC3B (A3B (Montrer SGCB Anticorps)) inhibited its activity.
APOBEC3B*c.783delG showed evidence of modest association with breast cancer and seemed to contribute to earlier onset of the disease.
Data show that APOBEC3B (A3B (Montrer SGCB Anticorps)) expression is inversely related to p53 (Montrer TP53 Anticorps) status in different cancer types and demonstrate that this is due to a direct and pivotal role for p53 (Montrer TP53 Anticorps) in repressing A3B (Montrer SGCB Anticorps) expression.
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation have been reported.
These results strongly imply that human and porcine APOBEC3 (Montrer APOBEC3F Anticorps) could inhibit porcine endogenous retroviruses replication in vivo, thereby reducing the risk of infection of human cells in the context of pig-to-human xenotransplantation.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
DNA dC->dU-editing enzyme APOBEC-3B
, cytidine deaminase
, phorbolin 2
, phorbolin 3
, phorbolin-1-related protein
, probable DNA dC->dU-editing enzyme APOBEC-3B
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
, DNA dC->dU-editing enzyme APOBEC3
, apolipoprotein B editing complex 3
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
, probable DNA dC->dU-editing enzyme APOBEC3
, apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B