Arachidonate 15-Lipoxygenase B Protéines (ALOX15B)

Human Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

1. ALOX15B expression and up-regulation in the functional and non-functional pituitary adenomas.

2. we identified a novel role for ALOX15B, and to a lesser extent ALOX15, in cholesterol homeostasis and CCL17 production in human macrophages.

3. Results demonstrate the expression of ALOX15 and ALOX15B in failing as well as in donor hearts. ALOX15/B signaling may play an important role in heart disease, including heart failure. Isolated fibroblasts from all four chambers of the heart expressed ALOX15 as well as ALOX15B, and gene expression levels were further increased under hypoxia.

4. Ca(2+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT domain.

5. 15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop.

6. these results demonstrate the strict regiospecificity of h15-LOX-2 that circumscribes its role in transcellular synthesis.

7. This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2.

8. The ALOX15B gene may be associated with coronary artery disease.

9. Hpoxia-induced pulmonary vascular remodeling is associated with increased levels of 15-LO-2.

10. ALOX15 rs11568070 polymorphisms did not discriminate for the disease or its severity.

11. 15-LOX2 expression inhibits Myc-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia.

12. activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin generation

13. Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension.

14. Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.

15. ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4, LPS and hypoxia.

16. Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.

17. The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity.

18. Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid.

19. In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms.

20. White tea extract induces apoptosis via PPAR gamma and 15-lipoxygenases.

Rabbit Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

1. Data show that 15-LOX-2 and its product, 15(S)-HETE, are important intermediates in hypoxia-induced rabbit pulmonary artery smooth muscle cells (PASMCs) proliferation and may participate in hypoxia-induced pulmonary hypertension.