Profil protéine

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ASAP2

• ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2) anticorps
• ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog (asap2.L) anticorps
• ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b (asap1b) anticorps
• ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (asap2) anticorps
• ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2) anticorps

• 6530401G17Rik anticorps
• AMAP2 anticorps
• asap2 anticorps
• CENTB3 anticorps
• Ddef2 anticorps
• Afficher tous les alias de synonymes
• Gm592 anticorps
• Gm1523 anticorps
• PAG3 anticorps
• PAP anticorps
• Pap-alpha anticorps
• SHAG1 anticorps
• si:dkey-37o8.2 anticorps

Protein level used designations for ASAP2

development and differentiation enhancing factor 2 , development- and differentiation-enhancing factor 2 , ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 , asap1 , PYK2 C terminus-associated protein , arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 , centaurin, beta 3 , development and differentiation-enhancing factor 2 , paxillin-associated protein with ARF GAP activity 3 , pyk2 C-terminus-associated protein