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ASAP3 encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. De plus, nous expédions ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Results show that ASAP3 was amplified in colorectal cancer (CRC (Montrer CALR Anticorps)) tissues, and its upregulation was associated with poor prognosis of patients with CRC (Montrer CALR Anticorps). Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO (Montrer IKBKG Anticorps). These results suggest that ASAP3 acts as an oncogene (Montrer RAB1A Anticorps).
The data, for the first time, link ASAP3 with ACTG1 (Montrer ACTG1 Anticorps) in the regulation of cytoskeletal maintenance and cell motility
). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion.
Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin (Montrer AMPH Anticorps), and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF (Montrer EGF Anticorps))-elicited membrane remodeling.
ACAP4 protein cooperates with Grb2 (Montrer GRB2 Anticorps) protein to orchestrate epidermal growth factor (Montrer EGF Anticorps)-stimulated integrin beta1 recycling in cell migration
The ArfGAP catalytic mechanism and shows a glutamine (Montrer GFPT1 Anticorps) from Arf6 (Montrer ARF6 Anticorps) and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.
ACAP4 is involved in ARF6 (Montrer ARF6 Anticorps)-mediated cell migration.
ASAP3 functions nonredundantly with ASAP1 (Montrer ASAP1 Anticorps) to control cell movement and may have a role in cancer cell invasion.
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1
, development and differentiation enhancing factor-like 1
, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
, ARF6 GTPase-activating protein
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
, centaurin, beta 6
, development and differentiation-enhancing factor-like 1
, protein up-regulated in liver cancer 1
, up-regulated in liver cancer 1 (UPLC1)