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Immunohistochemistry confirmed ARNT2 expression in cell sub-populations within proliferative zones of patients' glioblastoma. Decreased ARNT2 expression was consistently observed in non-tumorigenic glioblastoma cells, compared to tumorigenic cells. Moreover, ARNT2 expression correlated with a tumorigenic molecular signature at both the tissue level within the tumor core and at the single cell level in the patients' tumors
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Low expression of ARNT2 is associated with gastric cancer.
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The single nucleotide polymorphisms rs4778599 in the gene encoding aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), showed an association that survived correction for multiple testing with emotion recognition of audio-visual stimuli in women
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Attenuated ARNT2 expression in HCC827 cells greatly promoted tumor growth.
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nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38
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Data suggest that selected human SIM1 (single-minded homolog 1) variants exhibit poor dimerization with ARNT2 and anomalous intracellular localization; these data were used to predict 'hot-spot' in SIM1/SIM2 (residues 290-326) critical for function.
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These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation.
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mutation of ARNT2 results in absence of detectable levels of ARNT2 transcript and protein from patient fibroblasts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and loss of ARNT2 function.
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In white males, rs4072568 in ARNT2 was also associated with BMI (P = 9 x 10(-4)) and % body fat (P = 0.001).
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ARNT2 might play an important role in the modulation of HIF-1-regulated signaling and metabolism.
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promotes differentiation of IL-22-producing CD4(+) T-cells
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There is no association of ARNT2 gene with cleft palate only (n = 45) and cleft lip/palate (n = 37).
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We thus propose that NDN regulates neuronal function and hypoxic response by regulating the activities of the ARNT2:SIM1 and ARNT2:HIF1alpha dimers, respectively.
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a possible use of ARNT2 and GST A1 as prognostic breast cancer biomarkers.