Ataxin 2-Binding Protein 1 Protéines (A2BP1)

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. De plus, nous expédions Ataxin 2-Binding Protein 1 Anticorps (94) et Ataxin 2-Binding Protein 1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
A2BP1 54715 Q9NWB1
A2BP1 268859 Q9JJ43
A2BP1 302920  
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Showing 8 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
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Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 6 to 10 Days
$284.90
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
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Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,968.17
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Levure Cynomolgus His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,032.33
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Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,050.67
Détails

A2BP1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Ataxin 2-Binding Protein 1 (A2BP1) partenaires d'interaction

Zebrafish Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.

Chlamydomonas reinhardtii (C. reinhardtii) Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.

Human Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. RBFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.

  2. Low RBFOX1 expression is associated with aberrant splicing in Type 1 diabetes.

  3. Data show that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS, these proteins play important roles in developing neurons and are not completely functionally redundant.

  4. RBFOX1 - strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.

  5. Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5' of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.

  6. Report a 1.8 A X-ray structure of the free Fox-1 containing six distinct monomers. We use this and the nuclear magnetic resonance (NMR) structure of the Fox-1 protein/RNA complex for molecular dynamics (MD) analyses of the structured hydration. The individual monomers of the X-ray structure show diverse hydration patterns, however, MD excellently reproduces the most occupied hydration sites.

  7. Copy-number variations are enriched for RBFOX1 and other neurodevelopmental genes in children with developmental coordination disorder.

  8. We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements

  9. FGF12, RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT body patterning pathways and into the dosage effects of FGF12, RBFOX1, and MIR302F is warranted.

  10. Data indicate that multiple rare, coding variants in RBFOX1 protein associated with reduced systolic blood pressure (SBP).

  11. study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease

  12. The SNP rs1478697 in A2BP1 may be associated with antipsychotic induced weight gain induced by 8-week treatment with olanzapine.

  13. This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.

  14. Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism

  15. The Genome-wide association study showed a significant association for a variant within the RBFOX1 gene with generalized anxiety disorder.

  16. This study suggested that exonic RBFOX1 deletions are involved in the broad spectrum of focal and generalized epilepsies.

  17. RBFOX proteins can facilitate the splicing of micro-exons. We also found that PTBP1 likely regulates the inclusion of micro-exons, possibly by repressing the inclusion of micro-exons that are enhanced by RBFOX proteins and other splicing factors.[RBFOX]

  18. Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy

  19. Reduced RBFOX1 activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  20. RBFOX1 promotes the skipping of APP exon 7, but not the inclusion of exon 8.

Profil protéine Ataxin 2-Binding Protein 1 (A2BP1)

Profil protéine

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with A2BP1

  • RNA binding protein, fox-1 homolog 1 (RBFOX1)
  • RNA binding fox-1 homolog 1 (RBFOX1)
  • RNA binding fox-1 homolog 1 (rbfox1)
  • multicopper ferroxidase (FOX1)
  • RNA binding protein, fox-1 homolog (C. elegans) 1 (Rbfox1)
  • RNA binding protein, fox-1 homolog 1 (Rbfox1)
  • 2BP1 Protéine
  • A2bp Protéine
  • A2bp1 Protéine
  • fox-1 Protéine
  • FOX1 Protéine
  • Hrnbp1 Protéine
  • zgc:103635 Protéine

Protein level used designations for A2BP1

RNA binding protein, fox-1 homolog (C. elegans) 1 , ataxin 2-binding protein 1 , RNA binding protein fox-1 homolog 1 , ataxin-2-binding protein 1 , fox-1 homolog A , hexaribonucleotide-binding protein 1 , ataxin 2 binding protein 1 , hexaribonucleotide binding protein 1 , RNA binding protein, fox-1 homolog 1

GENE ID SPECIES
416645 Gallus gallus
453899 Pan troglodytes
100357475 Oryctolagus cuniculus
449554 Danio rerio
5720109 Chlamydomonas reinhardtii
54715 Homo sapiens
521304 Bos taurus
268859 Mus musculus
302920 Rattus norvegicus
100172936 Pongo abelii
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