Ataxin 2-Binding Protein 1 Protéines (A2BP1)

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. De plus, nous expédions Ataxin 2-Binding Protein 1 Anticorps (94) et Ataxin 2-Binding Protein 1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
A2BP1 54715 Q9NWB1
A2BP1 268859 Q9JJ43
A2BP1 302920  
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Showing 8 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
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Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher 6 to 10 Days
$284.90
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,968.17
Détails
Levure Cynomolgus His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,032.33
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Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,050.67
Détails

A2BP1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Ataxin 2-Binding Protein 1 (A2BP1) partenaires d'interaction

Zebrafish Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator (Montrer PTBP2 Protéines) rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.

Chlamydomonas reinhardtii (C. reinhardtii) Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway.

Human Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. Low RBFOX1 expression is associated with aberrant splicing in Type 1 diabetes.

  2. Data show that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS, these proteins play important roles in developing neurons and are not completely functionally redundant.

  3. RBFOX1 - strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.

  4. Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5' of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.

  5. Report a 1.8 A X-ray structure of the free Fox-1 containing six distinct monomers. We use this and the nuclear magnetic resonance (NMR) structure of the Fox-1 protein/RNA complex for molecular dynamics (MD) analyses of the structured hydration. The individual monomers of the X-ray structure show diverse hydration patterns, however, MD excellently reproduces the most occupied hydration sites.

  6. Copy-number variations are enriched for RBFOX1 and other neurodevelopmental genes in children with developmental coordination disorder.

  7. We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 and SRSF1 (Montrer SRSF1 Protéines) complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements

  8. FGF12 (Montrer FGF12 Protéines), RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT (Montrer WNT2 Protéines) body patterning pathways and into the dosage effects of FGF12 (Montrer FGF12 Protéines), RBFOX1, and MIR302F is warranted.

  9. Data indicate that multiple rare, coding variants in RBFOX1 protein associated with reduced systolic blood pressure (SBP (Montrer SHBG Protéines)).

  10. study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease

Mouse (Murine) Ataxin 2-Binding Protein 1 (A2BP1) interaction partners

  1. Study shows that Rbfox1-isoform1 plays an important role in neuronal migration and synapse network formation during corticogenesis. Defects in these critical processes may induce structural and functional defects in cortical neurons, and consequently contribute to the pathophysiology of neurodevelopmental disorders with RBFOX1 abnormalities.

  2. Upon picrotoxin treatment, Rbfox1 expression was downregulated by miR (Montrer MLXIP Protéines)-129-5p, thereby allowing the repression of Atp2b4 (Montrer ATP2B4 Protéines) and Dcx (Montrer DCX Protéines).

  3. Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism

  4. Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 (Montrer RBM9 Protéines) cooperate in promoting Mef2D (Montrer MEF2D Protéines) splicing and subsequent myogenesis.

  5. Rbfox1 regulates RNA splicing required for skeletal muscle structure and function.

  6. Fox-1, expressed specifically in the neural cell stage, promoted Mef2c (Montrer MEF2C Protéines) exon beta inclusion via the GCAUG.

  7. The results suggest that in neuronal tissues A2BP1 plays important roles, which are regulated in a spatiotemporal manner.

  8. our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1 (Montrer FRG1 Protéines), reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 (Montrer CAPN3 Protéines) protein through dysregulated splicing

  9. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation.

  10. The splicing regulator (Montrer PTBP2 Protéines) Rbfox1 controls neuronal excitation in the mammalian brain.

Profil protéine Ataxin 2-Binding Protein 1 (A2BP1)

Profil protéine

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with A2BP1

  • RNA binding protein, fox-1 homolog 1 (RBFOX1)
  • RNA binding fox-1 homolog 1 (RBFOX1)
  • RNA binding fox-1 homolog 1 (rbfox1)
  • multicopper ferroxidase (FOX1)
  • RNA binding protein, fox-1 homolog (C. elegans) 1 (Rbfox1)
  • RNA binding protein, fox-1 homolog 1 (Rbfox1)
  • 2BP1 Protéine
  • A2bp Protéine
  • A2bp1 Protéine
  • fox-1 Protéine
  • FOX1 Protéine
  • Hrnbp1 Protéine
  • zgc:103635 Protéine

Protein level used designations for A2BP1

RNA binding protein, fox-1 homolog (C. elegans) 1 , ataxin 2-binding protein 1 , RNA binding protein fox-1 homolog 1 , ataxin-2-binding protein 1 , fox-1 homolog A , hexaribonucleotide-binding protein 1 , ataxin 2 binding protein 1 , hexaribonucleotide binding protein 1 , RNA binding protein, fox-1 homolog 1

GENE ID SPECIES
416645 Gallus gallus
453899 Pan troglodytes
100357475 Oryctolagus cuniculus
449554 Danio rerio
5720109 Chlamydomonas reinhardtii
54715 Homo sapiens
521304 Bos taurus
268859 Mus musculus
302920 Rattus norvegicus
100172936 Pongo abelii
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