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May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Encodes a mitochondrial protein
Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin.
Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein).
Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma.
We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation.
AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported.
GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.
Plk1 controls Aurora A localization and function by regulating cellular levels of hBora.
Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents.
There exists an Ub-independent alternative pathway that promotesAurora-A degradation and AURKAIP1 promotes Aurora-A degradation through this Ub-independent yet proteasome-dependent pathway.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
aurora kinase A-interacting protein
, AURKA-interacting protein
, aurora kinase A interacting protein 1
, aurora-A kinase interacting protein
, Aurora-A kinase interacting protein