anti-BCL2-Associated Athanogene (BAG1) Anticorps

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. De plus, nous expédions BAG1 Protéines (19) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
BAG1 573 Q99933
BAG1 12017 Q60739
BAG1 297994 B0K019
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Top anti-BAG1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 132 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Souris Lapin Inconjugué IHC (p), WB Western blot analysis of Bag1 using anti-Bag1 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat kidney tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Bag1 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Bag1 at approximately 39KD. The expected band size for Bag1 is at 39KD. IHC analysis of Bag1 using anti-Bag1 antibody . Bag1 was detected in paraffin-embedded section of mouse testis tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Bag1 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
$280.00
Détails
Humain Lapin Inconjugué WB WB Suggested Anti-BAG1 Antibody Titration: 1.0 ug/ml Positive Control: Hela Whole Cell BAG1 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-BAG1 Antibody Titration: 1.0 ug/ml Positive Control: 721_B Whole Cell BAG1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of BAG1 expression in HEK293T (A), Raw264.7 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB 0.1 mg 6 to 8 Days
$478.50
Détails
Humain Lapin Inconjugué IF, IHC, WB Western blot analysis of extracts of SW620 and mouse kidney cell lines, using BAG1 antibody. 100 μL 11 to 13 Days
$366.77
Détails
Humain Souris Inconjugué IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to BAG1 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml] BAG1 monoclonal antibody (M02), clone 2D3 Western Blot analysis of BAG1 expression in HeLa . 100 μg 11 to 12 Days
$364.00
Détails
Humain Lapin Inconjugué ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Bag1, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: H1299 10% SDS PAGE Bag1 antibody antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué WB 0.1 mg 6 to 8 Days
$676.50
Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of BAG1 Antibody (C-term) (ABIN389451) in MDA-MB231 cell line lysates (35 µg/lane). BAG1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BAG1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 10 to 11 Days
$385.00
Détails

anti-BAG1 Anticorps mieux référencés

  1. Human Polyclonal BAG1 Primary Antibody pour IHC (p), WB - ABIN541543 : Nollen, Brunsting, Song, Kampinga, Morimoto: Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. dans Molecular and cellular biology 2000 (PubMed)
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  2. Human Polyclonal BAG1 Primary Antibody pour WB - ABIN541541 : Cato, Mink: BAG-1 family of cochaperones in the modulation of nuclear receptor action. dans The Journal of steroid biochemistry and molecular biology 2001 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BAG1 Primary Antibody pour WB - ABIN2477576 : Broström, Kronberg, Németh, Oxelbäck: The effect of shoulder muscle training in patients with recurrent shoulder dislocations. dans Scandinavian journal of rehabilitation medicine 1992 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal BAG1 Primary Antibody pour WB - ABIN2477577 : Liman, Ganesan, Dohm, Krajewski, Reed, Bähr, Wouters, Kermer: Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. dans Molecular and cellular biology 2005 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal BAG1 Primary Antibody pour IHC, IHC (p) - ABIN4282935 : Aust, Pils, Polterauer, Horvat, Cacsire Castillo-Tong, Pils, Dudek, Schmid, Speiser, Reinthaller, Grimm: Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer. dans Applied immunohistochemistry & molecular morphology : AIMM 2013 (PubMed)

  6. Mouse (Murine) Polyclonal BAG1 Primary Antibody pour IHC (p), WB - ABIN5518811 : Bai, Yi, Li, Sui: Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. dans World journal of gastroenterology 2007 (PubMed)

  7. Cow (Bovine) Polyclonal BAG1 Primary Antibody pour IHC, IHC (p) - ABIN4282933 : An, Li, Yao, Li, Wang, Sun, Li, Meng, Wang: BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. dans The Journal of cell biology 2017 (PubMed)

Plus d’anticorps contre BAG1 partenaires d’interaction

Human BCL2-Associated Athanogene (BAG1) interaction partners

  1. Study in human osteosarcoma line U2OS expressing a conditional MYC-ER allele revealed that small isoform of BAG1, BAG1S, in cooperation with the HSP70 chaperone complex, selectively mediates cell survival in MYC overexpressing tumor cells and identified a set of specific pro-survival clients controlled by the HSP70/BAG1S chaperone complex.

  2. Bag-1 targeted therapy might enhance the therapeutic potential of conventional anti-cancer drugs in the treatment of breast cancer.

  3. BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples.

  4. Targeting mTOR with rapamycin may significantly potentiate the inhibitory effect in BAG1silenced cells.

  5. Here the authors show that the AF-1 domain of AR is bound by the cochaperone Bag-1L.

  6. Over expression of BAG-1 may be a biomarker for cisplatin resistance in patients with primary or recurrent head and neck squamous cell carcinoma.

  7. Increased BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signaling.

  8. BAG-4/SODD, HSP70, and HSP90 are potential prognostic markers in node-negative breast carcinoma that merit further research.

  9. interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening

  10. These results suggest that Bag1 and Bag3 control the stability of the Hsc70-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 system.

  11. Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.

  12. the combined effects of BAG-1 and XPD polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.

  13. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.

  14. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.

  15. The expression of BAG-1 was upregulated in chronic non-eosinophilic rhinosinusitis.

  16. BAG-1 expression was high in esophageal carcinoma tissues compared to normal esophagus. After Eca109 cells were transfected with BAG-1-siRNA, the proliferation and invasive capabilities of the cells were decreased while the apoptosis rate was enhanced.

  17. BAG-1M mediates Hsp70 inhibition downstream of NF-kappaB.

  18. Forced Bag-1L expression prevented Cisplatin-induced apoptosis.

  19. distinct isoforms of BAG-1 had different anti-apoptotic ability in breast cancer cells treated with the 4-OH TAM.

  20. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes

Mouse (Murine) BCL2-Associated Athanogene (BAG1) interaction partners

  1. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.

  2. that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways

  3. These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions.

  4. The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.

  5. The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.

  6. Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment

  7. this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein.

  8. Bag-1 proteins function as regulators of the action of selective transcription factors.

  9. during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)

  10. Bag1 is a regulator and marker of neuronal differentiation

  11. BAG1 displays potent neuroprotective activity in vivo against stroke.

  12. Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.

  13. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.

  14. Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover

  15. BAG-1 associates with Tau protein in an Hsc70-dependent manner.

  16. BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments

  17. These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain.

  18. The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon.

  19. Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons.

BAG1 profil antigène

Profil protéine

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.

Gene names and symbols associated with BAG1

  • BCL2 associated athanogene 1 (BAG1) anticorps
  • putative bcl2-associated athanogene (Smp_005900) anticorps
  • BCL2-associated athanogene 1 (Bag1) anticorps
  • Bcl2 associated athanogene 1 (Bag1) anticorps
  • BAG family molecular chaperone regulator 1 (bag-1) anticorps
  • BCL-2-associated athanogene 1 (BAG1) anticorps
  • BAG family molecular chaperone regulator 1 (LOC781741) anticorps
  • BCL2-associated athanogene 1 (bag1) anticorps
  • ATBAG1 anticorps
  • Bag-1 anticorps
  • BCL-2-associated athanogene 1 anticorps
  • HAP anticorps
  • im:7148830 anticorps
  • MSG15.15 anticorps
  • MSG15_15 anticorps
  • Rap46 anticorps
  • si:dkey-216e9.4 anticorps

Protein level used designations for BAG1

BAG family molecular chaperone regulator 1 , Bcl-2 associating athanogene-1 protein , Bcl-2-binding protein , glucocortoid receptor-associated protein RAP46 , receptor-associated protein, 46-KD , bcl2-associated athanogene , BCL2-associated athanogene , bcl-2-associated athanogene 1 , hydroxysteroid (17-beta) dehydrogenase 3

GENE ID SPECIES
573 Homo sapiens
8342092 Schistosoma mansoni
100345469 Oryctolagus cuniculus
12017 Mus musculus
297994 Rattus norvegicus
172373 Caenorhabditis elegans
611781 Canis lupus familiaris
835281 Arabidopsis thaliana
781741 Bos taurus
558108 Danio rerio
100513225 Sus scrofa
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