BMP Binding Endothelial Regulator Protéines (BMPER)

BMPER encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. De plus, nous expédions BMPER Anticorps (36) et BMPER Kits (20) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
BMPER 168667 Q8N8U9
BMPER 73230 Q8CJ69
Rat BMPER BMPER 300455  
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Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails
Escherichia coli (E. coli) Souris S tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
Détails
Escherichia coli (E. coli) Humain S tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$698.00
Détails
Escherichia coli (E. coli) Souris Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
$540.11
Détails

BMPER Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,

Plus protéines pour BMP Binding Endothelial Regulator (BMPER) partenaires d'interaction

Fruit Fly (Drosophila melanogaster) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. The bone morphogenetic protein- binding protein Cv-2 negatively regulates bone morphogenetic protein signaling.

  2. Cv-2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling.

Zebrafish BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. The NMR structure of the Danio rerio CV2 VWC1 domain in its unbound state shows the key features for high affinity binding to BMP-2 (Montrer BMP4 Protéines) are a pre-oriented peptide loop.

  2. Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.

  3. LRP1 (Montrer LRP1 Protéines) acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 (Montrer BMP4 Protéines) to mediate the endocytosis of the Bmper/Bmp4 (Montrer BMP4 Protéines) signaling complex.

  4. Binding of CV2 to Chordin (Montrer CHRD Protéines) promotes BMP-2 (Montrer BMP4 Protéines) signaling.

  5. Cvl2 was identified as an essential pro-bone morphogenetic protein factor during zebrafish embryogenesis.

  6. Bmper is a conserved regulator of hematopoietic and vascular development in zebrafish.

  7. Initial crystallographic analysis suggests that a complete binary complex consisting of one BMP2 (Montrer BMP4 Protéines) dimer bound to two crossveinless 2 (CV2) von Willebrand type C (VWC1) domains is present in the asymmetric unit.

  8. The structure of the complex between CV-2 Von Willebrand factor (Montrer VWF Protéines) type C (VWC) domain 1 and BMP-2 (Montrer BMP4 Protéines), is reported.

Xenopus laevis BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.

Human BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. Overexpression of BMPER remarkably enhanced BMP-2 (Montrer BMP2 Protéines)-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo.

  2. that BMPER-modulated BMP pathway activity regulates VE-cadherin (Montrer CDH5 Protéines) expression and vascular barrier function

  3. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.

  4. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells.

  5. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (Montrer THBS1 Protéines) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

  6. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.

  7. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs.

  8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

  9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

  10. Mutual regulation by BMP-9 (Montrer GDF2 Protéines) and CV2 is essential in regulating the development of the vascular endothelium.

Cow (Bovine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. Results identified variant SNPs in BMPER gene associated with phenotypic variation in cattle that can be used as genetic markers for breeding.

Pig (Porcine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. BMPER promoter polymorphisms have an effect on the intramuscular fat deposition in longissimus dorsi muscle content.

Mouse (Murine) BMP Binding Endothelial Regulator (BMPER) interaction partners

  1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment.

  2. CV2 binds directly to BMP10 (Montrer BMP10 Protéines), as determined by co-immunoprecipitation, and inhibits BMP10 (Montrer BMP10 Protéines) from initiating SMAD (Montrer SMAD1 Protéines) signaling, as determined by luciferase reporter gene assays. BMP10 (Montrer BMP10 Protéines) and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells.

  3. BMPER/low-density lipoprotein receptor-related protein 1 (Montrer LRP1 Protéines) axis plays a pivotal role in pulmonary inflammatory response.

  4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (Montrer THBS1 Protéines) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

  5. BMPER-induced BMP signaling promotes coronary artery remodeling.

  6. BMPER appears to play a role in regulating both vessel density and cardiac development

  7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin (Montrer CDH1 Protéines) and epithelial leakage in vitro and in vivo.

  8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

  9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

  10. Bmper may play an important role in suppressing hepcidin (Montrer HAMP Protéines) production in hypotransferrinemic mice.

Profil protéine BMPER

Profil protéine

This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.

Gene names and symbols associated with BMPER

  • BMP binding endothelial regulator (BMPER)
  • crossveinless 2 (cv-2)
  • BMP binding endothelial regulator (bmper)
  • BMP-binding endothelial regulator protein (LOC100070275)
  • crossveinless 2 (cv2)
  • BMP binding endothelial regulator L homeolog (bmper.L)
  • BMP-binding endothelial regulator (Bmper)
  • 3110056H04Rik Protéine
  • BMPER Protéine
  • CG15671 Protéine
  • Crim3 Protéine
  • CT35855 Protéine
  • CV-2 Protéine
  • cv 2 Protéine
  • cv2 Protéine
  • cvl2 Protéine
  • Dmel\\CG15671 Protéine
  • id:ibd5071 Protéine
  • RGD1563373 Protéine

Protein level used designations for BMPER

BMP-binding endothelial regulator precursor protein , CG15671-PA , crossveinless-2 , cv-2-PA , BMP binding endothelial regulator , crossveinless 2 , BMP-binding endothelial regulator protein-like , BMP-binding endothelial regulator protein , cv2 , bone morphogenetic protein-binding endothelial cell precursor-derived regulator , hCV2

GENE ID SPECIES
100225434 Taeniopygia guttata
100349327 Oryctolagus cuniculus
45280 Drosophila melanogaster
463344 Pan troglodytes
733449 Xenopus (Silurana) tropicalis
100070275 Equus caballus
100303516 Saccoglossus kowalevskii
100415378 Callithrix jacchus
100472873 Ailuropoda melanoleuca
100605182 Nomascus leucogenys
338246 Danio rerio
734166 Xenopus laevis
420744 Gallus gallus
168667 Homo sapiens
534101 Bos taurus
475280 Canis lupus familiaris
100525197 Sus scrofa
73230 Mus musculus
300455 Rattus norvegicus
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