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BMX encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. De plus, nous expédions BMX Kits (18) et BMX Protéines (16) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal BMX Primary Antibody pour IHC - ABIN965689
Tamagnone, Lahtinen, Mustonen, Virtaneva, Francis, Muscatelli, Alitalo, Smith, Larsson, Alitalo: BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. dans Oncogene 1994
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Human Polyclonal BMX Primary Antibody pour IHC - ABIN965688
Qiu, Robinson, Pretlow, Kung et al.: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate ... dans Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Monoclonal BMX Primary Antibody pour ELISA, WB - ABIN968989
Palmer, Mutch, Workman, McDaid, Horwood, Foxwell: Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity. dans Blood 2008
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Human Monoclonal BMX Primary Antibody pour ELISA, WB - ABIN2869512
Kim, Jiang, Xie, Guo, Chen, Qiu: Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. dans Oncogene 2004
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These results suggested that BMX can promote cell proliferation through PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) and STAT3 (Montrer STAT3 Anticorps) signaling pathways in cervical cancer cells.
results demonstrate that cleaved BMX is a novel N-end rule substrate, and its degradation exhibits a novel interplay between substrate phosphorylation and N-end rule degradation, revealing an increasing complex regulatory network of apoptotic proteolytic signaling cascades.
Data indicate that EPHA3 (Montrer EPHA3 Anticorps) is involved in regulating the multidrug resistance (MDR) of small cell lung cancer (SCLC) via PI3K (Montrer PIK3CA Anticorps)/BMX/STAT3 (Montrer STAT3 Anticorps) signaling and may be a therapeutic target in SCLC.
BMX directly inhibits a core component of the intrinsic apoptosis machinery opens opportunities to improve the efficacy of existing chemotherapy by potentiating BAK (Montrer BAK1 Anticorps)-driven cell death in cancer cells.
Report BMX-ARHGAP gene fusion in gastric cardia adenocarcinoma.
These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.
BMX is an antiapoptotic downstream effector of PI3K (Montrer PIK3CA Anticorps), independent of AKT (Montrer AKT1 Anticorps).
The effects of dietary K(+) on Bmx were more pronounced
Overexpression of ETK is associated with the malignancy and disease progression of renal cell carcinoma (Montrer MOK Anticorps).
This review characterizes the role of BMX in inflamamtion, cardiovascular disease and cancer.
results suggest that the endothelial Bmx tyrosine kinase (Montrer TYRO3 Anticorps) could provide a target to attenuate the development of cardiac hypertrophy
Btk (Montrer BTK Anticorps), Tec (Montrer NR4A3 Anticorps), Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Tyrosine kinase (Montrer TYRO3 Anticorps) BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth.
genetic ablation of BMX conferred protection in arthritis model confirming BMX an essential mediator of inflammation in vivo; conclude BMX an essential component of inflammatory cytokine signaling and catalytic as well noncatalytic functions are involved
Investigate Bmx mediates VEGF (Montrer VEGFA Anticorps)-dependent lymphangiogenic signaling.
by preventing binding of Etk/Bmx to PAR(1 (Montrer MARK2 Anticorps)) -C-tail, hPar1 oncogenic properties are abrogated
activation of Etk largely co-localizes with TNFR2 (Montrer TNFRSF1B Anticorps) in vascular endothelial cells and cardiomyocytes.
Bmx overexpression accelerates keratinocyte proliferation and wound reepithelialization. Bmx expression also induces chronic inflammation and angiogenesis in the skin.
Role of Bmx in ischemia-mediated arteriogenesis/angiogenesis: response to ischemia, reduced in knockout mice and enhanced in transgenic mice.
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
BMX non-receptor tyrosine kinase
, cytoplasmic tyrosine-protein kinase BMX-like
, BTK-like on X chromosome
, Etk/Bmx cytosolic tyrosine kinase
, NTK38 tyrosine kinase
, bone marrow tyrosine kinase gene in chromosome X protein
, cytoplasmic tyrosine-protein kinase BMX
, epithelial and endothelial tyrosine kinase
, TYRO8 protein tyrosine kinase 8
, bone marrow tyrosine kinase gene in chromosome X protein homolog