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BICC1 encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. De plus, nous expédions BICC1 Protéines (3) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 56 products:
Human Polyclonal BICC1 Primary Antibody pour WB - ABIN1944768
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... dans Nature genetics 2003
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Human Polyclonal BICC1 Primary Antibody pour IHC (p), WB - ABIN390954
Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ... dans American journal of human genetics 2005
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These results demonstrate that the function of Bicc1 in the kidney is evolutionarily conserved, thus supporting the use of zebrafish as an alternative in vivo model to study the role of mammalian Bicc1 in renal cyst formation.
genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population.
Our findings suggested rs17648524 (intronic RBFOX1 gene) and rs7084402 (7.5kb 5' of the BICC1 gene) showed gender-specific associations with high myopia in the Han Chinese.
Suggest allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders.
Results provide some support for the involvement of BICC1 and PCLO (Montrer PCLO Anticorps) in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes
findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior
Polymorphisms in intron 2 of BICC1 are associated with its expression and bone (Montrer BEST1 Anticorps) mineral density (BMD)
The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes.
The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt (Montrer WNT2 Anticorps) inhibitory activity. The point mutation in the SAM (Montrer TTN Anticorps) domain results in a 22% loss of activity.
Polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms.
discovered that loss of the Pkd1 (Montrer PKD1 Anticorps) gene product, polycystin-1 (PC1 (Montrer PKD1 Anticorps)), whose mutation causes human autosomal dominant polycystic kidney disease (ADPKD), downregulates Bicc1 expression in vitro and in vivo
Bicc1 is a novel regulator of osteoblastogenesis and bone mineral density (BMD (Montrer BEST1 Anticorps))
Bicc1 KH domains bind the 3' UTRs of AC6 (Montrer ADCY6 Anticorps) and PKIa (Montrer PKIA Anticorps) mRNAs and cognate miRNA precursors, whereas the SAM (Montrer TTN Anticorps) domain loads a silencing complex with AGO2 (Montrer EIF2C2 Anticorps). AC6 (Montrer ADCY6 Anticorps) and PKIa (Montrer PKIA Anticorps) protein levels increase in cystic Bicc1-/- mouse kidneys.
lack of Bicc1 leads to disruption of normal cell-cell junctions.
Data suggest that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2 (Montrer PKD2 Anticorps) by antagonizing the repressive activity of the miR-17 microRNA family on the 3'UTR (Montrer UTS2R Anticorps) of Pkd2 (Montrer PKD2 Anticorps) mRNA.
Binds homoribopolymers in vitro; the third K homology domain is necessary and sufficient for in vitro Bicc1 RNA binding.
Bicc1 and SamCystin (Montrer ANKS6 Anticorps) interact at the protein level suggesting that they function in a common molecular pathway that when perturbed, is involved in cystogenesis.
Data report that targeted inactivation of BicC randomizes left-right asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow, and that BicC can uncouple Dvl2 (Montrer DVL2 Anticorps) signaling from the canonical Wnt (Montrer WNT2 Anticorps) pathway.
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
bicaudal C homolog 1 (Drosophila)
, bicaudal C homolog 1-like
, bicaudal C homolog 1
, protein bicaudal C homolog 1-like
, protein bicaudal C homolog 1
, juvenile congenital polycystic kidney disease
, polycystic kidney mutation of BALB/c origin