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Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).. De plus, nous expédions BOD1 Kits (6) et BOD1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal BOD1 Primary Antibody pour ELISA - ABIN4256618
Porter, McClelland, Khoudoli, Hunter, Andersen, McAinsh, Blow, Swedlow: Bod1, a novel kinetochore protein required for chromosome biorientation. dans The Journal of cell biology 2007
Kinetochore targeting of Bod1 depends on Ndc80 (Montrer NDC80 Anticorps) and not PP2A (Montrer PPP2R4 Anticorps)-B56. Bod1 depletion functionally affects Ndc80 (Montrer NDC80 Anticorps) phosphorylation at S55.
these results suggest that radiation alters miR (Montrer MLXIP Anticorps)-142-3p and Bod1 expression in carcinoma cells, and thus contributes to early stages of radiation-induced genomic instability
we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase.
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).
biorientation defective 1
, biorientation of chromosomes in cell division protein 1
, family with sequence similarity 44, member B
, biorientation defective protein 1
, bone length and organs 1