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BVES encodes a member of the POP family of proteins containing three putative transmembrane domains. De plus, nous expédions Blood Vessel Epicardial Substance Protéines (7) et et beaucoup plus de produits pour cette protéine.
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a loss of zBves affects the proteins involved in the pathway of the PAR (Montrer AFG3L2 Anticorps) junctional complex, especially aPKC, and both aPKC and Bves are indispensable to claudin expression.
Functional suppression of POPDC1 promoted breast cancer cell migration and proliferation, cAMP interacts with POPDC1 and up-regulates its expression in breast cancer cells.
recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 (Montrer POPDC2 Anticorps) and POPDC3 (Montrer POPDC3 Anticorps). POPDC proteins are transmembrane proteins, which are abundantly present in striated (Montrer NSDHL Anticorps) and smooth muscle cells. POPDC proteins bind cAMP with high affinity comparable to PKA
Study shows that EGFR (Montrer EGFR Anticorps) negatively regulates POPDC1 expression in breast cancer cell lines and that overexpression of POPDC1 can reduce EGFR (Montrer EGFR Anticorps)-mediated cell migration and proliferation in breast cancer cells.
BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Results also suggest that BVES promotes the post-translational degradation of c-Myc.
Forced expression of POPDC1(S201F) in a murine cardiac muscle cell line (HL-1 (Montrer ASGR1 Anticorps)) increased hyperpolarization and upstroke velocity of the action potential
These results suggest that down-regulation of BVES in hepatocellular carcinoma induces epithelial-mesenchymal transition, thus promoting invasion and metastasis in HCC (Montrer FAM126A Anticorps) cells.
Coding sequence and splice junctions of BVES were sequenced in 114 unrelated patients with Tetralogy of Fallot and 400 unrelated healthy individuals.Four novel BVES mutations were identified in patients with TOF (Montrer FEZF2 Anticorps) but not in the 400 controls.
Popdc1 (Bves) mod (Montrer POPDC2 Anticorps)ulates cardiac pacemaker activity in response (Montrer KCNAB2 Anticorps) to str (Montrer KCNK2 Anticorps)ess and displays high expression levels in the sinus node. The Popeye domain acts as a high-affinity cAMP binding domain and Popdc proteins interact with the ion channel TREK-1.
Low Bves expression is associated with gastric cancer progression.
BVES was found to be underexpressed in all stages of colorectal carcinoma and in adenomatous polyps, indicating its suppression occurs early in transformation.
BVES is a key regulator of intestinal stem cell programs and mucosal homeostasis.
BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Additionally, these results provide the first in vivo and genetic evidence supporting the hypothesis that BVES regulates Wnt (Montrer WNT2 Anticorps) activity.
Bves and NDRG4 (Montrer NDRG4 Anticorps) regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection.
Popdc1 and Popdc2 (Montrer POPDC2 Anticorps) proteins interact with the potassium channel (Montrer KCNAB2 Anticorps) TREK-1 (Montrer KCNK2 Anticorps), which leads to increased cell surface expression and enhanced current density
cell surface Bves/Pop1A is composed of an extracellular amino terminus, three transmembrane domains, and a cytoplasmic carboxyl terminus, which regulates cellular distribution of Bves/Pop1A during coronary vessel development
Bves directly interacts with GEFT and is a novel regulator of the Rac1 (Montrer RAC1 Anticorps) and Cdc42 (Montrer CDC42 Anticorps) signaling cascades.
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene.
popeye domain containing 1
, popeye domain-containing protein 1
, blood vessel epicardial substance
, Popeye domain-containing protein 1
, Popeye protein 1
, blood vessel epicardial substance-like
, popeye protein 1
, popeye 1
, popeye domain-containing 1
, POP1C protein
, popeye domain containing protein 1