anti-Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Anticorps

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. De plus, nous expédions BCAR3 Kits (12) et BCAR3 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
BCAR3 8412 O75815
BCAR3 29815 Q9QZK2
BCAR3 310838  
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Top anti-BCAR3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 51 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB BCAR3 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method BCAR3 was detected in paraffin-embedded sections of mouse lymphaden tissues using rabbit anti- BCAR3 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg 4 to 6 Days
$280.00
Détails
Souris Chèvre Inconjugué ELISA, WB   100 μg 6 to 7 Days
$429.84
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB ABIN6266858 at 1/100 staining human Breast cancer tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis on HeLa cell lysate using BCAR3 Antibody,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from HeLa/Jurkat cells, using BCAR3 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BCAR3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Chien Chèvre Inconjugué ELISA, WB 100 μg 11 to 14 Days
$610.50
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB ABIN6274127 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from HeLa cells using BCAR3 antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué EIA, IF, WB   0.1 mg 4 to 8 Days
$522.50
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
Détails
Humain Lapin Inconjugué IHC, IHC (p) Anti-BCAR3 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1100188 dilution 5 ug/ml. Anti-BCAR3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB   100 μL Disponible
$363.46
Détails

anti-BCAR3 Anticorps mieux référencés

  1. Mouse (Murine) Polyclonal BCAR3 Primary Antibody pour ELISA, WB - ABIN268560 : van Agthoven, van Agthoven, Dekker, van der Spek, Vreede, Dorssers: Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. dans The EMBO journal 1998 (PubMed)

  2. Human Polyclonal BCAR3 Primary Antibody pour IP, PLA - ABIN257737 : Sun, Cheng, Chen, Lim, Pallen: Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. dans Molecular and cellular biology 2012 (PubMed)

Plus d’anticorps contre BCAR3 partenaires d’interaction

Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. high expression level of BCAR3 predicted better prognosis of multiple myeloma patients.

  2. BCAR3 is an essential interactor and mediator of HEF1-induced migration.

  3. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta/Smad signaling pathway in invasive breast tumors.

  4. BCAR1 and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance

  5. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 translocation.

  6. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

  7. BCAR3 expression may regulate Src signaling in a BCAR3-p130(cas) complex-dependent fashion by altering the ability of the Src SH3 domain to bind the p130(cas) SBD

  8. BCAR3-p130Cas complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac activation or discohesion of epithelial breast cancer cells

  9. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes

  10. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner

  11. BCAR3 and NSP1 are more highly expressed than SH2D3C (SHEP1) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

  12. BCAR3 induces anti-estrogen resistance in breast tumor cell lines by altering cell-cell/cell-matrix interactions and cyclin D1 promoter activity.

  13. the spatial and temporal regulation of BCAR3/p130(Cas) interactions within the cell is important for controlling breast cancer cell motility

  14. BCAR3 protein, through its SH2 domain, is involved in the signaling pathways of EGF leading to cell cycle progression; BCAR3 itself is part of a mitogenic signaling pathway.

  15. The expression of breast cancer anti-estrogen resistance 3 results in basal serine phosphorylation of Crk-Associated Substrate Protein that normally occurs during adhesion of breast cancer cells to fibronectin.

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. The first spontaneous mutation in the Bcar3 gene associated with lens extrusion cataracts.

  2. data presented here suggest that Bcar3 could play a role in testis development

  3. many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas association

  4. p130Cas- and HEF1-associated AND-34 may regulate B cell adhesion and motility through a Cdc42-mediated signaling pathway.

  5. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1)

  6. AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens.

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns

BCAR3 profil antigène

Profil protéine

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCAR3

  • breast cancer anti-estrogen resistance 3 (BCAR3) anticorps
  • breast cancer anti-estrogen resistance 3 (Bcar3) anticorps
  • breast cancer anti-estrogen resistance 3 (bcar3) anticorps
  • breast cancer anti-estrogen resistance 3 L homeolog (bcar3.L) anticorps
  • AI131758 anticorps
  • AND-34 anticorps
  • BCAR3 anticorps
  • NSP2 anticorps
  • SH2D3B anticorps

Protein level used designations for BCAR3

SH2 domain-containing protein 3B , breast cancer anti-estrogen resistance protein 3 , breast cancer antiestrogen resistance 3 protein , dJ1033H22.2 (breast cancer anti-estrogen resistance 3) , novel SH2-containing protein 2 , p130Cas-binding protein AND-34 , breast cancer anti-estrogen resistance 3 , breast cancer antiestrogen resistance 3 , breast cancer anti-estrogen resistance protein 3-like

GENE ID SPECIES
8412 Homo sapiens
29815 Mus musculus
310838 Rattus norvegicus
424494 Gallus gallus
457032 Pan troglodytes
479941 Canis lupus familiaris
506231 Bos taurus
570610 Danio rerio
100059015 Equus caballus
100404661 Callithrix jacchus
100447373 Pongo abelii
100219682 Taeniopygia guttata
100029255 Monodelphis domestica
100155981 Sus scrofa
100352424 Oryctolagus cuniculus
100475875 Ailuropoda melanoleuca
100036719 Xenopus (Silurana) tropicalis
100593533 Nomascus leucogenys
432292 Xenopus laevis
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