Bridging Integrator 1 Protéines (BIN1)

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. De plus, nous expédions BIN1 Anticorps (118) et BIN1 Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
BIN1 274 O00499
BIN1 30948 O08539
BIN1 117028 O08839
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Top BIN1 Protéines sur anticorps-enligne.fr

Showing 9 out of 14 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag 20 μg Connectez-vous pour afficher 11 Days
$888.80
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 14 to 16 Days
$440.65
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,688.67
Détails
Escherichia coli (E. coli) Humain S tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$688.00
Détails
Escherichia coli (E. coli) Humain His tag   1 mg Connectez-vous pour afficher 2 to 3 Days
$3,655.38
Détails
Humain Inconjugué   20 μg Connectez-vous pour afficher 6 Days
$285.21
Détails

BIN1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Bridging Integrator 1 (BIN1) partenaires d'interaction

Human Bridging Integrator 1 (BIN1) interaction partners

  1. incidence of amnestic mild cognitive impairment (aMCI) in Tujia region of Enshi may be related to the rs744373 polymorphic site of BIN1 gene, ApoEepsilon2 is the protective factor and ApoEepsilon4 is the risk factor for aMCI in Tujia region of Enshi

  2. Meta-analysis validated the association of late onset Alzheimer disease with BIN1 (rs744373) variants.

  3. The findings reveal the ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau-induced pathobiological changes of the actin cytoskeleton.

  4. the association between the rs744373 polymorphism of BIN1 protein and late-onset Alzheimer's disease in East Asian, American, and European populations (Meta-Analysis)

  5. Italian family with centronuclear myopathy, carrying a novel pathogenic mutation of BIN1 gene in heterozygous state, consistent with autosomal dominant inheritance.

  6. bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations

  7. Findings indicated that BIN1 restoration in NSCLC could reverse PD-L1-mediated immune escape by inactivating the c-MYC and EGFR/mitogen-activated protein kinase pathways.

  8. propose that efforts to define how genetic variants in BIN1 elevate the risk for Alzheimer's disease would behoove to consider BIN1 function in the context of its main expression in mature oligodendrocytes

  9. The results emphasize an additional level of complexity in the regulation of the interaction between BIN1 and Tau dependent on the BIN1 isoforms.

  10. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1)

  11. Low Bin1 expression is associated with esophageal squamous cell carcinoma.

  12. the depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  13. BIN1 protein expression in cerebral cortex was related to disease progression in Alzheimer's Disease patients.

  14. data show that the previously described consensus sequence PXRPXR for amphiphysin SH3 ligands is inaccurate and instead define it as an extended Class II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine residues can give rise to extraordinary high SH3 binding affinity.

  15. findings support a contribution of BIN1 to individual differences in episodic memory performance among Type 2 Diabetes patients.

  16. analysis of a novel deregulated mechanism in chronic myeloid leukemia patients, indicating BIN1 and RIN1 as players in the maintenance of the abnormal RTK signaling in this hematological disease

  17. BIN1 is involved with late onset Alzheimer's disease. [review]

  18. This study supported that BIN1 contributes to the risk of Alzheimer's disease by altering neural degeneration (abnormal tau, brain atrophy and glucose metabolism) but not Abeta pathology

  19. Alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the age of onset of GBA-associated Parkinson.

  20. no association was found for either polymorphism, suggesting that these genes are not implicated in the aetiology of Alzheimer's disease in all populations.

Mouse (Murine) Bridging Integrator 1 (BIN1) interaction partners

  1. these results indicate that BIN1 and DNM2 regulate muscle development and organization, function through a common pathway, and define BIN1 as a negative regulator of DNM2 in vitro and in vivo during muscle maturation.

  2. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1)

  3. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD.

  4. the depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  5. Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  6. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions.

  7. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling.

  8. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts.

  9. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 is a mechanism by which serum starvation promotes E2F1-induced apoptosis.

  10. BIN1 interacts with MTM1 in skeletal muscle.

  11. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

  12. Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.

  13. Data have identified that membrane-associated BIN1 not only induces membrane curvature but can direct specific antegrade delivery of microtubule-transported membrane proteins.

  14. BIN1 is transcriptionally activated by E2F1 and mediates E2F1-induced apoptosis in response to DNA damage.

  15. findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphiphysin in membrane deformation

  16. Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking

  17. Bin1 has a developmentally critical role in cardiac muscle development

  18. the results define a function for Bin1 in apoptosis that is conditional on transformation stress.

  19. findings suggest that Bin1 loss promotes immune escape in cancer by deregulating indoleamine 2,3-dioxygenase (IDO) and that IDO inhibitors may improve responses to cancer chemotherapy

  20. In mouse tumors, Bin1 ablation facilitated progression to more aggressive invasive status.

Pig (Porcine) Bridging Integrator 1 (BIN1) interaction partners

  1. Report remodeling of the t-t nano-architecture in the post-MI heart that extends to the remote region and dysregulation of junctophilin-2 and bridging integrator 1.

Profil protéine BIN1

Profil protéine

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Gene names and symbols associated with Bridging Integrator 1 Protéines (BIN1)

  • bridging integrator 1 (BIN1)
  • bridging integrator 1 S homeolog (bin1.S)
  • bridging integrator 1 (bin1)
  • bridging integrator 1b (bin1b)
  • bridging integrator 1 (Bin1)
  • ALP-1 Protéine
  • AMPH2 Protéine
  • Amphl Protéine
  • BIN1 Protéine
  • BRAMP-2 Protéine
  • cb57 Protéine
  • MGC53185 Protéine
  • MGC76187 Protéine
  • SH3P9 Protéine
  • zgc:86701 Protéine

Protein level used designations for Bridging Integrator 1 Protéines (BIN1)

bridging integrator 1 , myc box-dependent-interacting protein 1-like , amphiphysin II , amphiphysin-like protein , box dependant MYC interacting protein 1 , box-dependent myc-interacting protein 1 , myc box-dependent-interacting protein 1 , SH3 domain-containing protein 9 , amphiphysin 2 , myc box dependent interacting protein 1 , Amph2 , amphiphysin IIamph2

GENE ID SPECIES
100052213 Equus caballus
380484 Xenopus laevis
394839 Xenopus (Silurana) tropicalis
447863 Danio rerio
735972 Pan troglodytes
100451162 Pongo abelii
100475668 Ailuropoda melanoleuca
100018912 Monodelphis domestica
100544136 Meleagris gallopavo
100599872 Nomascus leucogenys
274 Homo sapiens
30948 Mus musculus
424228 Gallus gallus
100037305 Sus scrofa
117028 Rattus norvegicus
483870 Canis lupus familiaris
614576 Bos taurus
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