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BRD1 encodes a protein of unknown function.
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TIMP-4 (Montrer TIMP4 Protéines), NT-proANP, NT-proBNP were strongest associated with PAF (Montrer PAF Protéines) and AHRE (Montrer AHR Protéines). The discriminatory performance of CHADS2-VASc for PAF (Montrer PAF Protéines) was increased by addition of selected biomarkers.
Structural and mechanistic insights into regulation of HBO1 (Montrer MYST2 Protéines) histone acetyltransferase activity by BRPF2 have been presented.
Reduced BRD1 expression is associated with Schizophrenia.
Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders.
The PHD (Montrer PDC Protéines) finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface.
Recognition of unmodified histone H3 (Montrer HIST3H3 Protéines) by the first PHD (Montrer PDC Protéines) finger of bromodomain-PHD finger protein 2 (Montrer PHF2 Protéines) provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF (Montrer KAT6B Protéines)).
BRD1 may have a role in schizophrenia and bipolar affective disorder
The association of BRD1 with schizophrenia in a Japanese population, was analysed.
These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.
Brd1(+/-) mice exhibit relational encoding deficits, compromised working and long term memory, as well as impaired executive cognitive functioning with cognitive behaviors relying on medial prefrontal cortex being particularly affected. Akin to patients with schizophrenia, the cognitive deficits displayed by Brd1(+/)(-) mice are not global, but selective.
results demonstrate widespread gene expression alterations in the brains of Brd1 +/- mice.
BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
Brd1-mediated Hbo1 (Montrer MYST2 Protéines) activity is crucial for efficient activation of CD8 (Montrer CD8A Protéines) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (Montrer CD8A Protéines) enhancers.
The Hbo1 (Montrer MYST2 Protéines)-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator (Montrer GIPC1 Protéines) genes.
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
bromodomain-containing protein 1
, bromodomain containing 1
, bromodomain containing protein 1
, bromodomain-containing protein 1-like
, BR140-like protein
, bromodomain and PHD finger-containing protein 2