Bromodomain Containing 1 Protéines (BRD1)

BRD1 encodes a protein of unknown function.

afficher tous les protéines Gène GeneID UniProt
Humain BRD1 BRD1 23774 O95696
Souris BRD1 BRD1 223770  
Rat BRD1 BRD1 315210  
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Showing 5 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 2 to 3 Days
Escherichia coli (E. coli) Humain His tag   100 μg Connectez-vous pour afficher 2 to 3 Days
Escherichia coli (E. coli) Humain His tag,DYKDDDDK Tag Recombinant BRD1 (556-688) activity using AlphaScreen. BRD1 (556-688) titration was assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRD1 (556-688) protein gel. BRD1 (556-688) protein was run on an SDS-PAGE gel and stained with Coomassie blue. 100 μg Connectez-vous pour afficher 1 to 2 Days
Escherichia coli (E. coli) Humain GST tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days

Plus protéines pour Bromodomain Containing 1 (BRD1) partenaires d'interaction

Human Bromodomain Containing 1 (BRD1) interaction partners

  1. TIMP-4 (Montrer TIMP4 Protéines), NT-proANP, NT-proBNP were strongest associated with PAF (Montrer PAF Protéines) and AHRE (Montrer AHR Protéines). The discriminatory performance of CHADS2-VASc for PAF (Montrer PAF Protéines) was increased by addition of selected biomarkers.

  2. Structural and mechanistic insights into regulation of HBO1 (Montrer MYST2 Protéines) histone acetyltransferase activity by BRPF2 have been presented.

  3. Reduced BRD1 expression is associated with Schizophrenia.

  4. Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders.

  5. The PHD (Montrer PDC Protéines) finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface.

  6. Recognition of unmodified histone H3 (Montrer HIST3H3 Protéines) by the first PHD (Montrer PDC Protéines) finger of bromodomain-PHD finger protein 2 (Montrer PHF2 Protéines) provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF (Montrer KAT6B Protéines)).

  7. BRD1 may have a role in schizophrenia and bipolar affective disorder

  8. The association of BRD1 with schizophrenia in a Japanese population, was analysed.

  9. These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.

Mouse (Murine) Bromodomain Containing 1 (BRD1) interaction partners

  1. Brd1(+/-) mice exhibit relational encoding deficits, compromised working and long term memory, as well as impaired executive cognitive functioning with cognitive behaviors relying on medial prefrontal cortex being particularly affected. Akin to patients with schizophrenia, the cognitive deficits displayed by Brd1(+/)(-) mice are not global, but selective.

  2. results demonstrate widespread gene expression alterations in the brains of Brd1 +/- mice.

  3. BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.

  4. Brd1-mediated Hbo1 (Montrer MYST2 Protéines) activity is crucial for efficient activation of CD8 (Montrer CD8A Protéines) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (Montrer CD8A Protéines) enhancers.

  5. The Hbo1 (Montrer MYST2 Protéines)-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator (Montrer GIPC1 Protéines) genes.

Profil protéine Bromodomain Containing 1 (BRD1)

Profil protéine

This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.

Gene names and symbols associated with BRD1

  • bromodomain containing 1 (BRD1)
  • bromodomain containing 1 L homeolog (brd1.L)
  • bromodomain containing 1a (brd1a)
  • bromodomain containing 1 (brd1)
  • bromodomain containing 1 (Brd1)
  • 1110059H06Rik Protéine
  • AI316859 Protéine
  • BDNF Protéine
  • brd1 Protéine
  • BRL Protéine
  • BRPF1 Protéine
  • BRPF2 Protéine
  • im:7138929 Protéine
  • LOC733743 Protéine
  • MGC80898 Protéine
  • MGC146307 Protéine
  • mKIAA4191 Protéine
  • si:dkey-164m14.6 Protéine

Protein level used designations for BRD1

bromodomain-containing protein 1 , bromodomain containing 1 , bromodomain containing protein 1 , bromodomain-containing protein 1-like , BR140-like protein , bromodomain and PHD finger-containing protein 2

100050039 Equus caballus
444273 Xenopus laevis
470245 Pan troglodytes
569574 Danio rerio
733743 Xenopus (Silurana) tropicalis
100477457 Ailuropoda melanoleuca
100586701 Nomascus leucogenys
23774 Homo sapiens
417731 Gallus gallus
481198 Canis lupus familiaris
100336626 Bos taurus
223770 Mus musculus
315210 Rattus norvegicus
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