anti-Bromodomain PHD Finger Transcription Factor (BPTF) Anticorps

BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. De plus, nous expédions et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
BPTF 2186 Q12830
BPTF 207165  
BPTF 303617  
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Showing 10 out of 35 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-FAC1 / BPTF antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 50 μL 11 to 14 Days
Humain Souris Inconjugué ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Western blot analysis using BPTF mAb against HEK293 (1) and BPTF (AA: 503-670) -hIgGFc transfected HEK293 (2) cell lysate. 100 μL 3 to 4 Days
Humain Lapin Inconjugué IP, WB   100 μL 11 to 14 Days
Humain Souris Inconjugué DB   100 μg 11 to 14 Days
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-BPTF/FALZ Polyclonal Antibody, Unconjugated (ABIN1386560) at 1:200 followed by conjugation to the secondary antibody and DAB staining Paraformaldehyde-fixed, paraffin embedded rat kidney, Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with 	BPTF/FALZ Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB staining. 100 μL 3 to 7 Days
Humain Souris Inconjugué WB   50 μg 11 to 14 Days
Humain Lapin Inconjugué IF, IHC, IHC (p), IP, WB   100 μL 11 to 14 Days
Humain Lapin Inconjugué IF, IHC, IHC (p)   100 μL 11 to 14 Days
Humain Lapin Inconjugué IF, IHC (p) Immunofluorescent staining of human cell line A-431 with BPTF polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. Immunohistochemical staining of human adrenal gland with BPTF polyclonal antibody  shows strong cytoplasmic positivity in cortical cells. 100 μL 11 to 12 Days
Humain Lapin Inconjugué IP, IHC, WB   100 μL 11 to 16 Days

anti-BPTF Anticorps mieux référencés

  1. Human Monoclonal BPTF Primary Antibody pour ELISA, WB - ABIN965692 : Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. dans The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal BPTF Primary Antibody pour ELISA, WB - ABIN968990 : Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. dans PLoS genetics 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal BPTF Primary Antibody pour ICC, IF - ABIN188587 : Goldman, Garlick, Kingston: Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. dans The Journal of biological chemistry 2010 (PubMed)

Plus d’anticorps contre BPTF partenaires d’interaction

Human Bromodomain PHD Finger Transcription Factor (BPTF) interaction partners

  1. Study identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. NMR could directly bind to chromatin regulator BPTF, and potentially promote MMP3 and MMP10 expression by ERK1/2 pathway through recruiting BPTF to chromatin.

  2. High BPTF expression is associated with gastric cancer growth and invasion.

  3. our data provide functional evidence and mechanistic insights that BPTF drives HCC progression, including promoting tumor cell proliferation, sustaining CSC traits, and increasing tumor metastasis, by transcriptionally activating the expression of hTERT.

  4. High BPTF expression in glioma tissue specimens was significantly associated with WHO grade and tumor size. Survival analysis revealed that the BPTF highexpression group had poorer overall and progressionfree survival compared with the lowexpression group.

  5. Haploinsufficiency of BPTF gene is associated with Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.

  6. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases

  7. NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1).

  8. Overexpression of BPTF is associated with melanoma cell survival and progression.

  9. somatic frameshift mutations of BPTF were present in gastric cancer and colorectal cancers

  10. BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers

  11. High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of colorectal cancer.

  12. expression may be marker for survival prediction in hepatocellular carcinoma

  13. The PHD-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level.

  14. the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype

  15. hkelch-like ECH-associated protein 1 regulates FAC1 in addition to its known role in control of Nrf2

  16. These findings suggest a role for FAC1 in apoptosis following release of Nrf2 from Keap1 in response to oxidative stress.

  17. crystallographic and NMR structures of the bromodomain-proximal PHD finger of BPTF in free and H3(1-15)K4me3-bound states

  18. High FALZ expression is associated with metastatic spread to the brain in primary non-small cell lung cancer.

Mouse (Murine) Bromodomain PHD Finger Transcription Factor (BPTF) interaction partners

  1. An essential requirement of the chromatin remodeler BPTF and NURF for activation of "stemness" gene-expression programs and proper function of adult HSCs.

  2. This study implicates BPTF in maintaining the unique epigenetic state of mammary gland stem cells.

  3. enhanced activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.

  4. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.

  5. We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.

  6. NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin

  7. Results suggest that BPTF/FAC1 is essential in the extraembryonic lineage for correct development of the ectoplacental cone and fetomaternal interactions.

  8. study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo

BPTF profil antigène

Profil protéine

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.

Gene names and symbols associated with BPTF

  • bromodomain PHD finger transcription factor (BPTF) anticorps
  • bromodomain PHD finger transcription factor (Bptf) anticorps
  • nucleosome-remodeling factor subunit NURF301 (LOC5576547) anticorps
  • fetal alzheimer antigen, falz (CpipJ_CPIJ011285) anticorps
  • bromodomain PHD finger transcription factor (bptf) anticorps
  • 9430093H17Rik anticorps
  • BPTF anticorps
  • FAC1 anticorps
  • Falz anticorps
  • NURF301 anticorps

Protein level used designations for BPTF

bromodomain and PHD domain transcription factor , bromodomain and PHD finger-containing transcription factor , fetal Alz-50 clone 1 protein , fetal Alz-50 reactive clone 1 , fetal Alzheimer antigen , nucleosome remodeling factor, large subunit , nucleosome-remodeling factor subunit BPTF , fetal alzheimer antigen, falz , bromodomain PHD finger transcription factor , nucleosome-remodeling factor subunit BPTF-like

2186 Homo sapiens
207165 Mus musculus
303617 Rattus norvegicus
5576547 Aedes aegypti
6043987 Culex quinquefasciatus
454840 Pan troglodytes
480467 Canis lupus familiaris
532986 Bos taurus
100063881 Equus caballus
100079560 Ornithorhynchus anatinus
100358904 Oryctolagus cuniculus
100494204 Xenopus (Silurana) tropicalis
100525424 Sus scrofa
100594415 Nomascus leucogenys
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