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BRWD1 encodes a member of the WD repeat protein family. De plus, nous expédions BRWD1 Kits (4) et BRWD1 Protéines (2) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal BRWD1 Primary Antibody pour WB - ABIN2776735
Hu, Warnatz, Vanhecke, Wagner, Fiebitz, Thamm, Kahlem, Lehrach, Yaspo, Janitz: Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. dans BMC genomics 2006
Study data indicate that, in both mice and humans, BRWD1 is a master orchestrator of enhancer accessibility that cooperates with transcription factor networks to drive late B-cell development.
RNA-seq evidence of biallelic expression of BRWD1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BRWD1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
isolation and characterization of the gene located in the Down Syndrome critical region-2 of chromosome 21
BRWD1 is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.
WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex
Brwd1 represents one of a small number of genes whose elimination disrupts gametogenesis in both sexes after the major events of meiotic prophase I have been completed.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
bromodomain and WD repeat domain containing 1
, WD repeat domain 9
, bromodomain and WD repeat domain containing 1, isoform 1
, bromodomain and WD repeat-containing protein 1-like
, WD repeat protein WDR9-form2
, WD repeat-containing protein 9
, bromodomain and WD repeat-containing protein 1
, transcriptional unit N143