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BRWD1 encodes a member of the WD repeat protein family.
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Cow (Bovine) Polyclonal BRWD1 Primary Antibody pour WB - ABIN2776735
Hu, Warnatz, Vanhecke, Wagner, Fiebitz, Thamm, Kahlem, Lehrach, Yaspo, Janitz: Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. dans BMC genomics 2006
RNA-seq evidence of biallelic expression of BRWD1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BRWD1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (Montrer WRB Anticorps) differentially methylated region (DMR (Montrer WDR20 Anticorps)) in disomic controls or trisomy (Down syndrome) individuals.
BRWD1 is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.
WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps) complex
Brwd1 represents one of a small number of genes whose elimination disrupts gametogenesis in both sexes after the major events of meiotic prophase I have been completed.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
bromodomain and WD repeat domain containing 1
, WD repeat domain 9
, bromodomain and WD repeat domain containing 1, isoform 1
, bromodomain and WD repeat-containing protein 1-like
, WD repeat protein WDR9-form2
, WD repeat-containing protein 9
, bromodomain and WD repeat-containing protein 1
, transcriptional unit N143