anti-C-Type Lectin Domain Family 4, Member D (CLEC4D) Anticorps

CLEC4D encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. De plus, nous expédions CLEC4D Protéines (10) et CLEC4D Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CLEC4D 338339 Q8WXI8
CLEC4D 17474 Q9Z2H6
CLEC4D 362432 Q69FH1
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Top anti-CLEC4D Anticorps sur anticorps-enligne.fr

Showing 10 out of 68 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of extracts of 293T , using CLEC4D antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277316 at 1/100 staining Human Head and neck cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC, WB 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué WB Western blot analysis in T47D cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using CLEC4D antibody (ABIN5971447) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Détails
Humain Souris PE FACS   100 Tests 11 to 14 Days
$1,013.83
Détails
Humain Souris APC FACS   100 Tests 11 to 14 Days
$1,101.83
Détails
Humain Lapin Inconjugué ELISA   100 μL 14 to 16 Days
$312.53
Détails
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human oral mucosa with CLEC4D polyclonal antibody  shows strong cytoplasmic positivity in squamous epithelial cells. Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with CLEC4D polyclonal antibody . 100 μL 11 to 12 Days
$637.32
Détails

anti-CLEC4D Anticorps mieux référencés

  1. Human Monoclonal CLEC4D Primary Antibody pour CyTOF, FACS - ABIN4900404 : Graham, Gupta, Schafer, Reid, Kimberg, Dennehy, Hornsell, Guler, Campanero-Rhodes, Palma, Feizi, Kim, Sobieszczuk, Willment, Brown: The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. dans The Journal of biological chemistry 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal CLEC4D Primary Antibody pour FACS - ABIN4897647 : Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. dans Journal of leukocyte biology 2017 (PubMed)

Plus d’anticorps contre CLEC4D partenaires d’interaction

Human C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells.

  2. Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants.

  3. CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule

  4. Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor.

Mouse (Murine) C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production.

  2. Dectin-3 deficiency did not lead to increased susceptibility of mice to experimental pulmonary C. neoformans infection. Also, no significant differences in pulmonary leukocyte recruitment and cytokine production were observed in Dectin-3 deficient mice compared to wild type infected mice

  3. activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner.

  4. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL (Clecsf8, Clec4d). Conversely, they show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  5. Data show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.

  6. MCL regulates the development of vaccine-induced Th17 cells and protective immunity against lethal experimental infection with Blastomyces dermatitidis.

  7. major contributor to activation of innate immunity against M. bovis in experimental model, mirrors Mincle expression

  8. Clecsf8-/- mice exhibit higher bacterial burdens and increased mortality upon Mycobacterium tuberculosis infection.

  9. These results suggest that MCL positively regulates Mincle expression through protein-protein interaction via its stalk region, thereby magnifying Mincle-mediated signaling.

  10. Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex.

  11. Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections.

  12. Clec4d(-/-) neutrophils did not exhibit any defect in bacterial clearance

  13. These results suggest that Clec4d is an FcRgamma-coupled activating receptor that mediates the adjuvanticity of trehalose-6,6'-dimycolate.

  14. The genomic organization of the MCL gene and the sequence of the promoter region were determined

CLEC4D profil antigène

Profil protéine

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4D

  • C-type lectin domain family 4 member D (CLEC4D) anticorps
  • C-type lectin domain family 4 member D (LOC611536) anticorps
  • C-type lectin domain family 4, member d (Clec4d) anticorps
  • C-type lectin domain family 4, member D (Clec4d) anticorps
  • CLEC-6 anticorps
  • CLEC4D anticorps
  • CLEC6 anticorps
  • Clecsf8 anticorps
  • Mcl anticorps
  • Mpcl anticorps

Protein level used designations for CLEC4D

C-type lectin domain family 4, member D , C-type lectin domain family 4 member D , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 , C-type lectin receptor , C-type lectin superfamily member 8 , C-type lectin-like receptor 6 , macrophage C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8 , C-type lectin, superfamily member 8 , macrophage-restricted C-type lectin

GENE ID SPECIES
473405 Pan troglodytes
611536 Canis lupus familiaris
616646 Bos taurus
338339 Homo sapiens
17474 Mus musculus
362432 Rattus norvegicus
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