Profil protéine

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332\; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CD209 Molecule Protéines (CD209)

• CD209 molecule (CD209) anticorps
• CD209 molecule (cd209) anticorps
• CD209a antigen (Cd209a) anticorps
• CD209 antigen-like protein D (LOC100529184) anticorps
• CD209c molecule (Cd209c) anticorps
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• CD209 antigen (LOC100460708) anticorps
• CD209 antigen (LOC105484282) anticorps

• Cd209 anticorps
• CDSIGN anticorps
• CIRE anticorps
• CLEC4L anticorps
• CLEC4M anticorps
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• DC-SIGN anticorps
• DC-SIGN1 anticorps
• Dcsign anticorps
• si:ch211-224h1.3 anticorps
• SIGN-R1 anticorps
• SIGNR5 anticorps

Protein level used designations for CD209 Molecule Protéines (CD209)

C-type lectin domain family 4 member L , C-type lectin domain family 4, member L , CD209 antigen , HIV gpl20-binding protein , dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin , CD209-like protein , DC-SIGN1 , dendritic cell-specific ICAM-3 grabbing non-integrin , C-type lectin domain family 4, member M , DC-SIGN protein , putative mannose-binding C-type lectin , CD209 antigen-like protein A , dendritic cell-specific ICAM-3-grabbing non-integrin , CD209 , CD209 antigen-like protein C , CD209c antigen , Dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific ICAM-3 grabbing nonintegrin