CD248 Molecule, Endosialin Protéines (CD248)

May play a role in angiogenesis or vascular function.. De plus, nous expédions CD248 Anticorps (83) et CD248 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CD248 57124 Q9HCU0
CD248 70445 Q91V98
Rat CD248 CD248 293669  
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Top CD248 Protéines sur anticorps-enligne.fr

Showing 3 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
$7,506.65
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails

CD248 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,
Mouse (Murine)
,

Plus protéines pour CD248 Molecule, Endosialin (CD248) partenaires d'interaction

Human CD248 Molecule, Endosialin (CD248) interaction partners

  1. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation

  2. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells.

  3. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer

  4. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis.

  5. Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas.

  6. CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker.

  7. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

  8. MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development.

  9. The authors show that endosialin, a C-type lectin, expressed in the liver exclusively by HSC and portal fibroblasts, is upregulated in liver fibrosis in mouse and man.

  10. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies.

  11. new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains

  12. [review] CD248 is a C-type lectin-like domain-containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions.

  13. CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD.

  14. endosialin can be detected in advanced sarcoma

  15. Endosialin expression may be involved in the progression of rectal cancers.

  16. Results provide evidence for a TEM-1-dependent signal pathway that controls proliferation of pericytes.

  17. TEM1/endosialin was induced in the vasculature of high-grade brain tumors where its expression was inversely correlated with patient age.

  18. Endosialin colocalized with thrombomodulin, suggesting the proteins may have complementary functions in tumor progression.

  19. Endosialin is a marker of stromal fibroblasts and is not selectively expressed on tumor endothelium.

  20. results pinpoint to a molecular mechanism by which expression of endosialin/TEM1 in the tumor stroma and endothelium may support tumor progression and invasion

Mouse (Murine) CD248 Molecule, Endosialin (CD248) interaction partners

  1. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer

  2. Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signaling.

  3. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis.

  4. suggest that CD248 stromal cells have a pathogenic role in renal fibrosis

  5. We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling.

  6. Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several tumor models.

  7. Expression of CD248 was seen in osteoblasts, but not osteoclasts. CD248(-/-) mouse tibiae had higher bone mass and superior mechanical properties compared to WT mice. Primary osteoblasts from CD248(-/-) mice induced increased bone mineralization

  8. The multiple pathways regulated by the cytoplasmic domain of CD248 highlight its potential as a therapeutic target to treat cancer.

  9. our observations suggest that Tem1 is expressed throughout embryonic and adult development in several types of mesenchymal cells closely related to blood vessels.

  10. required for efficient lymph node expansion

  11. Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process

  12. In the embryo when analysed by confocal microscopy endosialin on vessels does not colocalise with endothelial cells expressing CD31, rather, endosialin is restricted to closely associated perivascular cells that also express the pericyte marker NG2.

  13. CD248 expression helps define a subset of lymphoid tissue stromal cells which play a role in remodelling during tissue development, infection and repair

Profil protéine CD248

Profil protéine

May play a role in angiogenesis or vascular function.

Gene names and symbols associated with CD248

  • CD248 molecule (CD248)
  • CD248 antigen, endosialin (Cd248)
  • CD248 molecule (Cd248)
  • CD248 molecule, endosialin a (cd248a)
  • 2610111G01Rik Protéine
  • AI842296 Protéine
  • Cd164l1 Protéine
  • fb96b12 Protéine
  • Tem1 Protéine
  • wu:fb96b12 Protéine
  • zgc:162651 Protéine

Protein level used designations for CD248

2610111G01Rik , CD164 sialomucin-like 1 , CD248 antigen, endosialin , endosialin , tumor endothelial marker 1 , CD248 molecule, endosialin , CD248 molecule, endosialin a

GENE ID SPECIES
57124 Homo sapiens
70445 Mus musculus
293669 Rattus norvegicus
520070 Bos taurus
483712 Canis lupus familiaris
100346780 Oryctolagus cuniculus
100714474 Cavia porcellus
323364 Danio rerio
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