anti-CD96 (CD96) Anticorps

Mouse (Murine) CD96 interaction partners

1. Blockade of CD96 completely restored the expansion and inflammatory properties of CD96(high) Th9 cells

2. knock-out mice display hyperinflammatory responses to lipopolysaccharide and resistance to lung carcinogenesis

3. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.

4. CD96-driven adhesion to CD155 may be crucial in developmental processes

Human CD96 interaction partners

1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells

2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice.

3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes

4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects.

5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course.

6. CD96 could serve as a target structure for effector cell-mediated lysis.

7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression.

8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells.

9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells

10. CD96-driven adhesion to CD155 may be crucial in developmental processes