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The protein encoded by CDC14A is a member of the dual specificity protein tyrosine phosphatase family.
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Human Polyclonal CDC14A Primary Antibody pour ICC, IF - ABIN4296773
Imtiaz, Belyantseva, Beirl, Fenollar-Ferrer, Bashir, Bukhari, Bouzid, Shaukat, Azaiez, Booth, Kahrizi, Najmabadi, Maqsood, Wilson, Fitzgerald, Tlili, Olszewski, Lund, Chaudhry, Rehman, Starost et al.: CDC14A phosphatase is essential for hearing and male fertility in mouse and human. ... dans Human molecular genetics 1970
We demonstrate that XCdc14A upregulation prevents targeting of exocyst and SNARE (Montrer NAPA Anticorps) complexes to the midbody, both essential for abscission to occur.
Cdc14B (Montrer CDC14B Anticorps) knockout (Cdc14B (Montrer CDC14B Anticorps)(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy.
Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness.
Overexpressed miR (Montrer MLXIP Anticorps)-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR (Montrer MLXIP Anticorps)- 301a may be useful for osteosarcoma diagnosis and therapy.
These findings indicated that ZIPK (Montrer DAPK3 Anticorps) may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A.
These data support the hypothesis that Cdc14A counteracts Cdk1 (Montrer CDK1 Anticorps)-cyclin B1 (Montrer CCNB1 Anticorps) activity through Wee1 (Montrer WEE1 Anticorps) dephosphorylation.
CDC (Montrer CDK1 Anticorps) (cell division cycle) 14A/B phosphatases associate with KIBRA (Montrer WWC1 Anticorps), and CDK1 (Montrer CDK1 Anticorps)-non-phosphorylatable KIBRA (Montrer WWC1 Anticorps) has greatly reduced interaction with CDC14B (Montrer CDC14B Anticorps).
Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.
Cdc14A phosphatase prevents premature activation of Cdk1 (Montrer CDK1 Anticorps) regulating Cdc25A (Montrer CDC25A Anticorps) and Cdc25B (Montrer CDC25B Anticorps) at the entry into mitosis.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
human Cdc14A phosphatase disrupts centrosome separation
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14A
, dual specificity protein phosphatase CDC14A
, CDC14 cell division cycle 14 homolog A
, cell division cycle 14 homolog A
, CDC14 homolog A
, CDC14 cell division cycle 14 homolog A (S. cerevisiae)
, dual specificity protein phosphatase CDC14A-like
, CDC10 (cell division cycle 10, S. cerevisiae, homolog)