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Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity).. De plus, nous expédions CDKN2A Interacting Protein Protéines (7) et CDKN2A Interacting Protein Kits (6) et beaucoup plus de produits pour cette protéine.
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a comprehensive current understanding into the molecular mechanisms of CARF functions in regulation of DNA damage response, cell cycle checkpoints, cell survival and death signaling pathways.
report that CARF (Collaborator of ARF) is a new target of miR (Montrer MLXIP Anticorps)-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB (Montrer RB1 Anticorps), HDM2 and p21(WAF1 (Montrer CDKN1A Anticorps))
Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin (Montrer CTNNB1 Anticorps)/TCF (Montrer HNF4A Anticorps) signaling.
CARF promotes carcinogenesis in p53 (Montrer TP53 Anticorps)-deficient cells by repressing p21WAF1 and promoting cell cycle progression.
The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 (Montrer XRN2 Anticorps) between the nucleoplasm and nucleolus.
CARF regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66 (Montrer WDR66 Anticorps), USP20 (Montrer USP20 Anticorps) and OR7C2 (Montrer OR7C2 Anticorps) in a Korean population.
CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM (Montrer ATM Anticorps) and gammaH2AX (Montrer H2AFX Anticorps), leading to induction of mitotic arrest and eventual apoptosis.
CARF may act as a novel key regulator of the p53 (Montrer TP53 Anticorps) pathway at multiple checkpoints
cooperates with human p14ARF in activating p53 (Montrer TP53 Anticorps)
Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity).
, collaborates/cooperates with ARF (alternate reading frame) protein
, collaborator of ARF
, CDKN2A interacting protein
, protein CDKN2AIP homolog A