anti-CREB Regulated Transcription Coactivator 1 (CRTC1) Anticorps

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. De plus, nous expédions CRTC1 Protéines (8) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CRTC1 23373 Q6UUV9
CRTC1 382056 Q68ED7
CRTC1 684527 Q157S1
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB L1 rat brain, L2 human colon carcinoma lysates probed (ABIN746558) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 73kDa HeLa cells probed with Rabbit Anti-Torc1 (Ser151) Polyclonal Antibody . 100 μL 3 to 7 Days
Boeuf (Vache) Lapin Inconjugué EIA, WB   0.1 mg 4 to 8 Days
Humain Lapin Inconjugué ELISA, WB Western blot analysis of Torc1/Crtc1 (Phospho-Ser151) using PMA treated Jurkat whole cell lysates 100 μL 11 to 12 Days
Humain Souris Inconjugué ELISA, FACS, IHC, IHC (p) Human Liver, Hepatocytes: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
Humain Souris Inconjugué ELISA, FACS, IF/ICC, WB 100 μL 11 to 16 Days
Boeuf (Vache) Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with CRTC1 antibody ABIN214337 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CRTC1 / MECT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500. 50 μg 11 to 14 Days
Humain Souris Inconjugué ELISA, WB   100 μL Disponible
Humain Souris Inconjugué ELISA, WB   100 μL Disponible
Humain Souris Inconjugué ICC, FACS, ELISA, WB Figure 1: Flow cytometric analysis of K562 cells using CRTC1 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green) . Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. 100 μL 3 to 4 Days
Humain Lapin Inconjugué WB Lane 3: Recombinant Human CRTC1 Protein 2.5ng 100 μg 4 to 6 Days

anti-CRTC1 Anticorps mieux référencés

  1. Human Monoclonal CRTC1 Primary Antibody pour ICC, FACS - ABIN969066 : Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. dans Genes, chromosomes & cancer 2007 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre CRTC1 partenaires d’interaction

Human CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. Case Reports: identify a novel recurrent gene fusion, CRTC1-SS18, in undifferentiated small round cell sarcoma.

  2. Pancreatic mucoepidermoid carcinoma does not have CRTC1/3-MAML2 fusion gene and MAML2 gene rearrangement.

  3. Two cases of breast mucoepidermoid carcinomas harboring CRTC1-MAML2 fusions are reported

  4. mTORC1 hyperactivation in melanocytes results in hypopigmentation.

  5. CRTC1-TRIM11 fusion appears to be specific of an unpigmented nodular tumor combining a melanocytic phenotype and low-grade tumor behavior.

  6. LINC00473 acts as a promising biomarker and therapeutic target for human CRTC1-MAML2-positive Mucoepidermoid carcinomas.

  7. Pharmacological inhibition of mTORC1 by rapamycin in PHA-stimulated PBL reduced viral replication to the level found in unstimulated lymphocytes, indicating that mTORC1 activity supports MV replication as a proviral host factor.

  8. SNP located in CRTC1 has been shown in GWAS studies to be significantly associated with the risk of Barrett's esophagus.

  9. This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1.

  10. CRTC1 negatively regulates lipogenic gene expression in liver.

  11. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker

  12. modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 and MYC activity

  13. High TORC1 expression is associated with meningioma and schwannoma.

  14. MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma

  15. CRTC1 as new mediator of PGE2 signaling

  16. Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells

  17. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma

  18. CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.

  19. DNA methylation levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.

  20. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC diagnosis but is not associated with differences in survival outcomes.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. These results indicate that neuronal activity induces a preferential binding of CRTC1 to the transcriptional complex in CRE/TATA-containing promoters to engage activity-dependent transcription in neurons.

  2. GRK5 is critical for normal mTORC1 signaling and connectivity in medial prefrontal cortex and normal social behavior.

  3. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity.

  4. CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR-34a.

  5. the HDAC3-N-CoR corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1, phosphorylated CREB, and histone acetyltransferase CBP induces transient transcription.

  6. Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.

  7. this study shows that mTORC1 activation is required for fueling B cells prior to dark zone proliferation rather than for allowing cell-cycle progression itself and must be regulated dynamically during cyclic re-entry to ensure efficient affinity-based selection

  8. Three mouse CRTCs (Crtc1, Crtc2 and Crtc3) exhibit distinct patterns of 14-3-3 binding at three conserved sites corresponding to S70, S171, and S275 (in CRTC2).

  9. The NR2B-CREB-miR212/132-CRTC1-CREB signal network plays an important role in the regulation of pain.

  10. Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.

  11. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  12. Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf and Nr4a1-2. By acting downstream of CRTC1, the HDAC inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.

  13. IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA synthesis, leading to increased histone acetylation and macrophage gene induction.

  14. Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain.

  15. This study demonstrates that TSC1- mechanistic target of rapamycin complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  16. These data identify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  17. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 [mTORC1]

  18. CRTC1 has a wide impact on CREB-dpendent memory processes and fine-tunes CREB output in a region-specific manner.

  19. Translational activation of CREB is caused by elevated phospho-elF2alpha.

  20. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade.

CRTC1 profil antigène

Profil protéine

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Gene names and symbols associated with CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1) anticorps
  • CREB regulated transcription coactivator 1 (Crtc1) anticorps
  • CREB regulated transcription coactivator 1 (crtc1) anticorps
  • CREB regulated transcription coactivator 1b (crtc1b) anticorps
  • AI413414 anticorps
  • crtc1 anticorps
  • fc68c05 anticorps
  • Mect1 anticorps
  • mKIAA0616 anticorps
  • pde4cb anticorps
  • R74955 anticorps
  • si:ch211-255d18.1 anticorps
  • si:ch211-255d18.8 anticorps
  • TORC-1 anticorps
  • TORC1 anticorps
  • WAMTP1 anticorps
  • wu:fc68c05 anticorps

Protein level used designations for CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated 1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , CH211-255D18.10 , CH211-255D18.9 , CREB regulated transcription coactivator 1b , cAMP-specific 3',5'-cyclic phosphodiesterase 4C , phosphodiesterase 4C, cAMP-specific b , zfTorc1

23373 Homo sapiens
382056 Mus musculus
510465 Bos taurus
684527 Rattus norvegicus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100523662 Sus scrofa
100548464 Meleagris gallopavo
571344 Danio rerio
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