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Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).. De plus, nous expédions CUEDC2 Protéines (9) et CUEDC2 Kits (7) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal CUEDC2 Primary Antibody pour ICC, ELISA - ABIN1030352
Chen, Wang, Mu, Luo, Liu, Liang, Zhuo, Hao, Wang, Fang, Bai, Wang, Wang, Jin, Gong, Zhou, Zhang, Xia, Li: Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon Cancer. dans Cell reports 2014
Low CUEDC2 expression is associated with glioma.
findings show a correlation between the aberrant expression of CUEDC2, and GLUT3 (Montrer SLC2A3 Anticorps) and LDHA (Montrer LDHA Anticorps) in clinical hepatocellular carcinoma samples, further demonstrating a link between CUEDC2 and the Warburg effect during cancer development
Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC (Montrer APC Anticorps)/C(Cdh1 (Montrer CDH1 Anticorps))-mediated cyclin A (Montrer CCNA2 Anticorps) destruction, cyclin-dependent kinase 2 (Montrer CDKL2 Anticorps) inactivation, and G1 arrest.
a new biological activity for CUEDC2 as the regulator of JAK1 (Montrer JAK1 Anticorps)/STAT3 (Montrer STAT3 Anticorps) signaling and the mechanism by which SOCS3 (Montrer SOCS3 Anticorps) has been linked to suppression of the JAK (Montrer JAK3 Anticorps)/STAT (Montrer STAT1 Anticorps) pathway
CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC (Montrer APC Anticorps)/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 (Montrer CDK1 Anticorps) during mitosis.
These results identify a key post-translational mechanism that controls progesterone receptor (Montrer PGR Anticorps) protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33 (Montrer TRIM33 Anticorps))-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1 (Montrer GPX1 Anticorps)) ubiquitination, and proteasome-dependent degradation.
These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB (Montrer NFKB1 Anticorps) and STAT3 (Montrer STAT3 Anticorps) signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell.
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).
CUE domain-containing protein 2-A
, mitotic phosphoprotein 38
, CUE domain containing 2
, CUE domain-containing protein 2-B
, CUE domain-containing protein 2