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The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al., 2004 [PubMed 14573622]).[supplied by OMIM, Mar 2008].. De plus, nous expédions CLMP Protéines (21) et CLMP Kits (12) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal CLMP Primary Antibody pour ELISA, WB - ABIN4281764
Raschperger, Engstrom, Pettersson, Fuxe: CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. dans The Journal of biological chemistry 2003
We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene. We identified two heterozygous mutations in CLMP, one in intron 1 (c.28+1G>C) from the father, the other on exon 4 (c502C>T, p.R168X) from the mother.
Inhibition of CFTR (Montrer CFTR Anticorps) or histone deacetylase (HDAC (Montrer HDAC1 Anticorps)) enhanced CAR expression while CFTR (Montrer CFTR Anticorps) overexpression or restoration of the diminished HDAC (Montrer HDAC3 Anticorps) activity in cystic fibrosis (Montrer S100A8 Anticorps) cells reduced CAR expression.
Novel inherited variants in CLMP were identified in three congenital short bowel syndrome patients derived from two unrelated families.
The key processes involved in intestinal epithelial development appear to be unaffected by wild type-CLMP or mutant-CLMP.
Coxsackievirus and adenovirus receptor (Montrer CXADR Anticorps) gene expression is induced in esophageal cancer cells by the HDAC (Montrer HDAC3 Anticorps) inhibitor trichostatin A.
The PDZ1 and PDZ3 domains of MAGI-1 (Montrer MAGI1 Anticorps) regulate the eight-exon isoform of the CXADR-like membrane protein.
Loss-of-function mutations in CLMP cause congenital short bowel syndrome in human beings, likely by interfering with tight-junction formation, which disrupts intestinal development.
CLMP is a novel cell-cell adhesion molecule (Montrer PCDHB16 Anticorps) and a new component of epithelial tight junctions.
We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker (Montrer VSIG1 Anticorps) in Xenopus) gene family, which may be the critical adhesion molecule (Montrer NCAM1 Anticorps) in adipocyte differentiation and development of obesity.
ASAM, IGSF11 (Montrer IGSF11 Anticorps), CXADR (Montrer CXADR Anticorps) and ESAM (Montrer ESAM Anticorps) are type I transmembrane proteins and members of the same IGSF superfamily.
Data (including data from studies in transgenic mice) suggest that, when Acam/Clmp is abundantly expressed on plasma membrane of mature adipocytes, mice are protected from obesity and diabetes with prominent reduction of adipose tissue mass and smaller size of adipocytes; studies used high-fat, high-sucrose diet to induce obesity and diabetes in control mice.
Expression of CLMP, a novel tight junction protein (Montrer OCLN Anticorps), is mediated via the interaction of GATA (Montrer QRSL1 Anticorps) with the Kruppel family proteins, KLF4 (Montrer KLF4 Anticorps) and Sp1 (Montrer SP1 Anticorps), in mouse TM4 (Montrer TPM4 Anticorps) Sertoli cells.
TNFalpha (Montrer TNF Anticorps)-mediated mRNA degradation of the CLMP gene is controlled by TTP (Montrer ZFP36 Anticorps) through the JNK (Montrer MAPK8 Anticorps) signalling cascade
The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al., 2004
CAR-like membrane protein
, adipocyte adhesion molecule
, adipocyte-specific adhesion molecule
, coxsackie- and adenovirus receptor-like membrane protein
, visceral adipose tissue-specific transmembrane protein OL-16
, adipocyte-specific protein 5