anti-Carbonic Anhydrase IX (CA9) Anticorps

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. De plus, nous expédions Carbonic Anhydrase IX Protéines (23) et Carbonic Anhydrase IX Kits (15) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CA9 230099 Q8VHB5
CA9 313495  
CA9 768 Q16790
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Top anti-Carbonic Anhydrase IX Anticorps sur anticorps-enligne.fr

Showing 10 out of 257 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB Western blot analysis of Carbonic Anhydrase 9 expression in HeLa (A), Ramos (B), Molt4 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL 6 to 8 Days
$522.50
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL 6 to 8 Days
$522.50
Détails
Humain Souris Inconjugué FACS, ELISA, WB 0.1 mg 3 to 4 Days
$430.10
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL 11 to 13 Days
$359.79
Détails
Cheval Souris APC FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$478.77
Détails
Cheval Souris PE FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$478.77
Détails
Cheval Souris PerCP FACS, IF, IHC (f), WB 250 μL 3 to 4 Days
$478.77
Détails
Cheval Souris Inconjugué FACS, IF, IHC (f), WB 50 μL 3 to 4 Days
$492.31
Détails
Humain Lapin Inconjugué IHC (p), ELISA   100 μL 14 to 16 Days
$247.82
Détails

anti-Carbonic Anhydrase IX Anticorps mieux référencés

  1. Dog (Canine) Polyclonal CA9 Primary Antibody pour ChIP, ELISA - ABIN151877 : Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? dans Gut 2007 (PubMed)
    Show all 179 Pubmed References

  2. Dog (Canine) Polyclonal CA9 Primary Antibody pour ELISA, ICC - ABIN251625 : Bui, Seligson, Han, Pantuck, Dorey, Huang, Horvath, Leibovich, Chopra, Liao, Stanbridge, Lerman, Palotie, Figlin, Belldegrun: Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2003 (PubMed)
    Show all 7 Pubmed References

  3. Polyclonal CA9 Primary Antibody pour IHC (fro), IF - ABIN540761 : Yoo, Baia, Smith, McDermott, Bollen, Vandenberg, Lamborn, Lal: Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)
    Show all 5 Pubmed References

  4. Dog (Canine) Polyclonal CA9 Primary Antibody pour ELISA, IHC (fro) - ABIN251626 : Sathornsumetee, Cao, Marcello, Herndon, McLendon, Desjardins, Friedman, Dewhirst, Vredenburgh, Rich: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. dans Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal CA9 Primary Antibody pour CyTOF, ELISA - ABIN4287748 : Cai, Alshehri, Choksi, Pestronk: Regional ischemic immune myopathy: a paraneoplastic dermatomyopathy. dans Journal of neuropathology and experimental neurology 2014 (PubMed)
    Show all 4 Pubmed References

  6. Human Polyclonal CA9 Primary Antibody pour CyTOF, FACS - ABIN4900431 : Swayampakula, McDonald, Vallejo, Coyaud, Chafe, Westerback, Venkateswaran, Shankar, Gao, Laurent, Lou, Bennewith, Supuran, Nabi, Raught, Dedhar: The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. dans Oncogene 2017 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal CA9 Primary Antibody pour ELISA, WB - ABIN545603 : Span, Bussink, Manders, Beex, Sweep: Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. dans British journal of cancer 2003 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal CA9 Primary Antibody pour FACS, ELISA - ABIN1724882 : Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. dans Histology and histopathology 2011 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal CA9 Primary Antibody pour IHC, ELISA - ABIN1724883 : Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. dans Breast cancer research and treatment 2012 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal CA9 Primary Antibody pour IF (p), IHC (p) - ABIN752773 : Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. dans Journal of the American Heart Association 2015 (PubMed)

Plus d’anticorps contre Carbonic Anhydrase IX partenaires d’interaction

Mouse (Murine) Carbonic Anhydrase IX (CA9) interaction partners

  1. In response to hypoxia, pancreatic ductal adenocarcinoma cells that express activated KRAS increase expression of carbonic anhydrase 9, via stabilization of HIF1A and HIF2A, to regulate pH and glycolysis.

  2. Lack of CAIX results in persistent acid backflux via claudin-18 downregulation, causing loss of parietal cells, hypergastrinaemia and foveolar hyperplasia.

  3. Authors demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.

  4. Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.

  5. constitutive activation of the NF-kappaB pathway in CAIX-depleted cells restored G-CSF secretion

  6. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes.

  7. CA IX may directly or indirectly play novel functions in brain tissue.

  8. about half the CA-dependent muscular lactate flux occurs across the surface membrane, while the other half occurs across the membranes of the T tubuli

  9. Data show that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1, but not LOX, in SCCVII tumors.

  10. a novel role for CA IX in the regulation of immunologic processes and digestion

  11. although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach

  12. These results suggest that the loss of function of cytosolic CA II in the stomach of Car2-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.

  13. CA9 may regulate ion and pH homeostasis within the developing embryo.

  14. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response

  15. that expression of CA9 is regulated through both the HIF-1 and unfolded protein response hypoxia response pathways in vitro and in vivo.

Human Carbonic Anhydrase IX (CA9) interaction partners

  1. HIF-1alpha, GLUT-1 and CA-IX may be connected with tumor response to preCRT, however, there is still skepticism towards their clinical use as predictors of outcome.

  2. hese findings may be of clinical significance, because carbonic anhydrase IX is overexpressed in the majority of clear cell renal cell carcinomas and in approximately 30% of colorectal cancers. The targeted delivery of IL2 helps potentiate the action of targeted cytotoxics, leading to cancer eradication in models that cannot be cured by conventional chemotherapy

  3. Study in rat xenograft model of renal clear cell carcinoma (RCCC) showed that expression of G250 had a certain correlation with the pathological changes of RCCC and expressions of Bax and Bcl-2 were up-regulated in the RCCC group compared to a healthy control. Results suggest G250 as a new specific marker of RCCC and joint detection of Bax and Bcl-2 can be used as an important index for the diagnosis of RCCC.

  4. Our data demonstrates that HIF-1alpha-mediated CA9 induction differs between patient-derived PDAC cells and that APE1/Ref-1 redox inhibition attenuates this induction by decreasing hypoxia-induced HIF-1 DNA binding. Dual-targeting of APE1/Ref-1 and CA9 in 3D spheroids demonstrated that this combination effectively kills PDAC tumor cells displaying drastically different levels of CA9.

  5. In response to hypoxia, pancreatic ductal adenocarcinoma cells that express activated KRAS increase expression of carbonic anhydrase 9, via stabilization of HIF1A and HIF2A, to regulate pH and glycolysis.

  6. CAIX acidifies the tumor microenvironment, and provides an extracellular pH control mechanism. CAIX thus acts as an extracellular pH-state, maintaining an acidic tumor extracellular pH that is tolerated by cancer cells and favors invasion and metastasis.

  7. Hypoxic stress-related adaptation - highlighted by CAIX expression - results in cellular quiescence in Hodgkin-Reed-Sternberg (HRS) cells , potentially contributing to the short-term failure of the standard chemotherapy in classical Hodgkin's lymphoma.

  8. High CA9 expression is associated with esophageal squamous cell carcinoma tumor growth.

  9. CA IX/COX-2 interplay can promote hypoxia survival and the invasion of tumor cells. These proteins may represent independent prognostic factors of colorectal cancer.

  10. Carbon anhydrase IX expression in lichen and leukoplakia epithelia shows that hypoxia plays a role in the pathogenesis of both lesions. The different distribution patterns provides further evidence of the different biological behavior of these two entities, which under certain circumstances can have similar clinical and histological features

  11. MUC5B and CA9 are highly conserved during gallbladder cance rhistological progression

  12. CA9/CAIX is an independent prognostic factor for oral squamous cell carcinoma patients.

  13. Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

  14. High membranous CA9 expression is associated with clear cell renal cell carcinoma.

  15. Results find that CAIX expression was increased in soft tissue and associated with worse disease-free survival.

  16. Positive CAIX cytoplasmic expression was significantly associated with lymph node affected and with disease-specific survival in oral squamous cell carcinoma.

  17. we identified an SNP in the CA9 3'UTR as a novel diagnostic and prognostic factor for HCC. The rs1048638-A genotype significantly affects miR-34a targeting and expression levels of CA9. The miR-34a-CA9 axis is important in controlling tumor growth and metastasis of HCC cells.

  18. CAIX and CAXII expression are diagnostic for breast cancer subtype and prognosticators of patient survival. Overall, we show that CAIX but not CAXII drives growth, migration, and metastasis consistent with its expression in more aggressive breast cancers.

  19. Our findings indicated that CA-IX may be a potential prognostic biomarker in the treatment of glioblastoma multiforme

  20. Our results do not suggest a prognostic role for CA IX overexpression in stage III non-small cell lung cancer patients who received neoadjuvant treatment.

Carbonic Anhydrase IX (CA9) profil antigène

Profil protéine

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Gene names and symbols associated with CA9

  • carbonic anhydrase 9 (CA9) anticorps
  • carbonic anhydrase 9 (CAH9) anticorps
  • carbonic anhydrase 9 (Car9) anticorps
  • Ca9 anticorps
  • CAIX anticorps
  • MN anticorps
  • MN/CA9 anticorps

Protein level used designations for CA9

carbonic anhydrase IX , carbonic anhydrase 9 , CA-IX , carbonate dehydratase IX , membrane antigen MN homolog , P54/58N , RCC-associated antigen G250 , RCC-associated protein G250 , carbonic dehydratase , membrane antigen MN , pMW1 , renal cell carcinoma-associated antigen G250

GENE ID SPECIES
473223 Pan troglodytes
511923 Bos taurus
5726457 Chlamydomonas reinhardtii
230099 Mus musculus
313495 Rattus norvegicus
768 Homo sapiens
611933 Canis lupus familiaris
100152792 Sus scrofa
770004 Gallus gallus
100337777 Oryctolagus cuniculus
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