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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. De plus, nous expédions Carbonic Anhydrase IX Kits (58) et Carbonic Anhydrase IX Protéines (25) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 302 products:
Dog (Canine) Polyclonal CA9 Primary Antibody pour ChIP, ELISA - ABIN151877
Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? dans Gut 2007
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Dog (Canine) Polyclonal CA9 Primary Antibody pour ELISA, ICC - ABIN251625
Bui, Seligson, Han, Pantuck, Dorey, Huang, Horvath, Leibovich, Chopra, Liao, Stanbridge, Lerman, Palotie, Figlin, Belldegrun: Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2003
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Dog (Canine) Polyclonal CA9 Primary Antibody pour ELISA, IHC (fro) - ABIN251626
Sathornsumetee, Cao, Marcello, Herndon, McLendon, Desjardins, Friedman, Dewhirst, Vredenburgh, Rich: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. dans Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008
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Human Monoclonal CA9 Primary Antibody pour CyTOF, ELISA - ABIN4287748
Cai, Alshehri, Choksi, Pestronk: Regional ischemic immune myopathy: a paraneoplastic dermatomyopathy. dans Journal of neuropathology and experimental neurology 2014
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Human Monoclonal CA9 Primary Antibody pour FACS, ELISA - ABIN1724882
Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. dans Histology and histopathology 2011
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Human Monoclonal CA9 Primary Antibody pour IHC, ELISA - ABIN1724883
Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. dans Breast cancer research and treatment 2012
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Human Polyclonal CA9 Primary Antibody pour IF (p), IHC (p) - ABIN752773
Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. dans Journal of the American Heart Association 2015
Human Monoclonal CA9 Primary Antibody pour FACS, IHC - ABIN2717028
Wang, Cheng, Liu, Zhang, Li, Li: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. dans Cellular signalling 2015
Human Polyclonal CA9 Primary Antibody pour CyTOF, FACS - ABIN4900431
Swayampakula, McDonald, Vallejo, Coyaud, Chafe, Westerback, Venkateswaran, Shankar, Gao, Laurent, Lou, Bennewith, Supuran, Nabi, Raught, Dedhar: The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. dans Oncogene 2017
Human Monoclonal CA9 Primary Antibody pour FACS - ABIN4897691
McIntyre, Patiar, Wigfield, Li, Ledaki, Turley, Leek, Snell, Gatter, Sly, Vaughan-Jones, Swietach, Harris: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Authors demonstrate that CAIX associates with MMP14 (Montrer MMP14 Anticorps) through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14 (Montrer MMP14 Anticorps)-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 (Montrer MMP14 Anticorps) catalytic activity.
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (Montrer NFKB1 Anticorps) pathway in CAIX-depleted cells restored G-CSF (Montrer CSF3 Anticorps) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (Montrer COL10A1 Anticorps) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (Montrer SLC2A1 Anticorps) and LOX (Montrer LOX Anticorps) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (Montrer SLC2A1 Anticorps), but not LOX (Montrer LOX Anticorps), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (Montrer CA2 Anticorps) in the stomach of Car2 (Montrer CA2 Anticorps)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
The TCGA data revealed that CAIX expression was significantly higher in bladder cancer specimens than in normal tissue.
CAIX enzyme inhibition assay showed the IC50 values in nM range. Though all the three compounds (1-3) showed a good binding with CAIX, compound 2 showed the best inhibition of CAIX activity. These compounds were non-toxic on normal cell lines (HEK (Montrer EPHA3 Anticorps)-293) and significantly inhibit the proliferation of hypoxic cancer cells
CA9 expression was observed in normal islets, while neuroendocrine microadenomas and small (< 1 cm) pancreatic neuroendocrine neoplasms/tumors showed CA9 expression loss.
Study revealed that CA9 expression was a pivotal predictive factor for poor prognosis after radical surgery for HCC (Montrer FAM126A Anticorps). Moreover, the CA9 regulation of the expression of EMT (Montrer ITK Anticorps)-related molecules represented a mechanism that enhanced malignant potential.
Report weak CA9 immunoreactivity in majority of CA9 positive colorectal carcinoma cases associated with macroscopic growth pattern.
Molecular characterization of carbonic anhydrase IX catalytic domain has been presented.
Authors present evidence that enhanced autophagy does not play a role in the enhanced growth of the CA9+ cells. Our study suggests a direct in vivo functional link between hypoxic cells and CICs in primary cervix cancer xenografts.
Genetic disruption of the intracellular pH-regulating proteins Na+/H+ exchanger 1 (SLC9A1 (Montrer SLC9A1 Anticorps)) and carbonic anhydrase 9 reduces the proliferation of colon cancer cells.
combined CA9-/CD147-capture antibodies demonstrated high efficiency for capturing circulating renal cell carcinoma (Montrer MOK Anticorps) cells
Data show that targeting the hypoxic tumor compartment by knockdown of carbonic anhydrase IX (CAIX) using short hairpin RNA or by chemical inhibition of CAIX with acetazolamide potentiates the anti-cancer activity of mTOR (Montrer FRAP1 Anticorps) inhibitors rapamycin.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250