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CEACAM1 overexpression in TSCC promoted tumor formation and growth.
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IRF1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately regulate CEACAM1 transcription, alternative splicing, and translation and may significantly contribute to CEACAM1 silencing in cancer.
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Study concludes that CEACAM1 is an important regulator of virus-specific CD8+ T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8+ T cells.
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regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction
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These experiments also confirmed that protein levels of CEACAM-1, which functions in cell adhesion, is dependent on LLO biosynthesis in vivo. Kato III cells and the MPDU1-rescued Kato IIIM cells therefore provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo.
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The MAPK-driven CEACAM1p activity is mediated by ETS1.
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CEACAM1 mRNA or protein expression are independent prognostic markers for ovarian cancer carcinomas.
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We suggest that CEACAM1 could be a prognostic marker of oral squamous cell carcinoma and oral carcinoma in situ. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ
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GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved.
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CEACAM1 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti.
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HBx, VEGF and CEACAM1 were widely expressed in HBV-related HCC. HBx may facilitate occurrence and progression of HBV-related HCC via down-regulating CEACAM1 and up-regulating VEGF.
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these data identify CEACAM1 as a clinically highly interesting target in multiple sclerosis pathogenesis and open new therapeutic avenues for the treatment of the disease.
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serum levels of CEACAM1 in healthy pregnant women were much lower than in non-pregnant women
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CEACAM1 overexpression significantly suppressed MM cell proliferation, induced cell apoptosis, and inhibited cell invasion and migration possibly through activation of caspase-3 and downregulation of MMP-2 and MMP-9.
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Data suggest that the serum level of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) may be used to discriminate gastrointestinal cancer patients from health controls.
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In this paper, a dual-target electrochemical aptasensor has been developed for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)6(3+) electronic wires
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Furthermore, the proposed aptasensor was successfully applied in determining CEA in serum samples, showing its superior prospects in clinical diagnosis.
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we show here that Human Metapneumovirus (HMPV)-infected cells upregulates CEACAM1 to restrict HMPV infection
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Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells.
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Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6.
