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STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. De plus, nous expédions Cbl-Interacting Protein Sts-1 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70 (Montrer ZAP70 Anticorps).
The results show that the interaction between STS-1 and ShcA (Montrer SHC1 Anticorps) is regulated in response to EGF receptor (Montrer EGFR Anticorps) activation.
The study reveals a role of CBL (Montrer CBL Anticorps) in restricting myeloid proliferation of human AML1 (Montrer RUNX1 Anticorps)-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
targeting Aurora B (Montrer AURKB Anticorps) to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
These results show that TULA-2 is a target of miR (Montrer MLXIP Anticorps)-148a-3p
This recovery involves the phosphorylation of p70 (Montrer ANXA6 Anticorps) independent of mTOR (Montrer FRAP1 Anticorps).
results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells
UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.
Ablation of TULA-2 resulted in hyperphosphorylation of Syk (Montrer SYK Anticorps) and its downstream effector phospholipase C (Montrer PLC Anticorps)-gamma2 as well as enhanced GPVI (Montrer GP6 Anticorps)-mediated platelet functional responses.
Sts-1 and Sts-2 (Montrer UBASH3A Anticorps) bind to Cbl (Montrer CBL Anticorps) and inhibit endocytosis of receptor tyrosine kinases
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of Zap70 (Montrer ZAP70 Anticorps).
Sts-1 and Sts-2 (Montrer UBASH3A Anticorps) are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.
dephosphorylation of Tyr (Montrer TYR Anticorps)(P)(346) may be considered an important "checkpoint" in the regulation of Syk (Montrer SYK Anticorps) activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr (Montrer TYR Anticorps)(P)(346) may include deactivation of receptor-activated Syk (Montrer SYK Anticorps) or suppression of Syk (Montrer SYK Anticorps) activation by suboptimal stimulation.
Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells.
The lack of TULA-2 facilitates T-cell responses to TCR/CD3 (Montrer CD3E Anticorps) stimulation, thus exacerbating T-cell-dependent inflammation.
TULA-2 negatively regulates osteoclast differentiation and function.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase (Montrer YES1 Anticorps) Syk (Montrer SYK Anticorps) interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Cbl-interacting protein Sts-1
, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
, T-cell ubiquitin ligand 2
, cbl-interacting protein p70
, nm23-phosphorylated unknown substrate
, suppressor of T-cell receptor signaling 1
, tyrosine-protein phosphatase STS1/TULA2
, ubiquitin-associated and SH3 domain-containing protein B